The application of mesenchymal stromal cells (MSCs) and their derivative exosome in skin wound healing: a comprehensive review.
The application of mesenchymal stromal cells (MSCs) and their derivative exosome in skin wound healing: a comprehensive review.
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DOI：
10.1186/s13287-021-02697-9
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发表时间：
2022-01-24
影响因子：
7.5
通讯作者：
Zamani A
中科院分区：
文献类型：
--
作者：
Bian D;Wu Y;Song G;Azizi R;Zamani A
最近，间充质基质细胞（MSC）及其外泌体已成为组织工程和再生医学背景下改变游戏规则的工具。间充质干细胞因其具有建立成纤维细胞和角质形成细胞等皮肤细胞的能力，以及抑制伤口部位炎症的独特属性，越来越受到学者的关注。此外，MSC还具有通过分泌促血管生成因子诱导血管生成的能力，并具有显着的抗纤维化活性，这主要是通过释放基质金属蛋白酶（MMP）介导的，这使其成为加速小疤痕伤口愈合的合理有效的策略。由于 MSC 的主要愈合特性取决于其旁分泌作用，因此 MSC 衍生的外泌体似乎也可以作为一种创新的无细胞方法作为支持伤口愈合和皮肤再生的替代选择。这种外泌体将功能性货物（例如，生长因子、细胞因子、miRNA等）从MSC传递到靶细胞，从而影响受体皮肤细胞的生物事件，例如迁移、增殖以及ECM成分（例如胶原蛋白）的分泌。与亲代间充质干细胞相比，外泌体疗法的主要优点是肿瘤形成的风险降低，免疫原性也较低。在此，我们概述了最近的体内报告，这些报告显示基于 MSC 的疗法可缓解皮肤伤口愈合，从而改善患有此类疾病的患者的生活质量。
Recently, mesenchymal stromal cells (MSCs) and also their exosome has become a game-changing tool in the context of tissue engineering and regenerative medicine. MSCs due to their competencies to establish skin cells, such as fibroblast and keratinocyte, and also their unique attribute to suppress inflammation in wound site has attracted increasing attention among scholars. In addition, MSC’s other capabilities to induce angiogenesis as a result of secretion of pro-angiogenic factors accompanied with marked anti-fibrotic activities, which mainly mediated by the releases matrix metalloproteinase (MMPs), make them a rational and effective strategy to accelerate wound healing with a small scar. Since the chief healing properties of the MSCs depend on their paracrine effects, it appears that MSCs-derived exosomes also can be an alternative option to support wound healing and skin regeneration as an innovative cell-free approach. Such exosomes convey functional cargos (e.g., growth factor, cytokine, miRNA, etc.) from MSCs to target cells, thereby affecting the recipient skin cells’ biological events, such as migration, proliferation, and also secretion of ECM components (e.g., collagen). The main superiorities of exosome therapy over parental MSCs are the diminished risk of tumor formation and also lower immunogenicity. Herein, we deliver an overview of recent in vivo reports rendering the therapeutic benefits of the MSCs-based therapies to ease skin wound healing, and so improving quality of life among patients suffering from such conditions.
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