Axonal injury in young pediatric head trauma: a comparison study of β-amyloid precursor protein (β-APP) immunohistochemical staining in traumatic and nontraumatic deaths.
Axonal injury in young pediatric head trauma: a comparison study of β-amyloid precursor protein (β-APP) immunohistochemical staining in traumatic and nontraumatic deaths.
复制标题
DOI：
10.1111/j.1556-4029.2011.01814.x
复制
发表时间：
2011-09
影响因子：
1.6
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Johnson MW;Stoll L;Rubio A;Troncoso J;Pletnikova O;Fowler DR;Li L
我们测试了β淀粉样前体蛋白（β APP）免疫组织化学染色作为幼儿死亡中脑外伤证据的独立效用。盲审人员回顾性地审查了他杀死亡、年龄匹配的无创伤证据的对照病例以及婴儿猝死综合症（SIDS）病例的免疫染色脑组织。审查人员正确识别了七名有头部外伤记录的病例中的五名。然而，7 个年龄匹配的对照病例中的 1 个和 10 个 SIDS/婴儿期不明原因猝死 (SUDI) 病例中的 1 个表现出与遭受创伤的病例相似的染色模式。我们讨论这些病例及其周围环境，旨在解释与轴突损伤的免疫组织学解释相关的困难。尽管 β APP 的效用非常强大（如果不与全身缺氧缺血性损伤混淆的话），但最终，β APP 研究应该只是确定死亡原因和死亡方式的一条信息。
We tested the independent utility of β amyloid precursor protein (β APP) immunohistochemical staining as evidence of brain trauma in the deaths of young children. Blinded reviewers retrospectively reviewed immunostained brain tissues from homicidal deaths, age matched control cases without evidence of trauma, as well as cases of sudden infant death syndrome (SIDS). The reviewers correctly identified five of the seven cases with documented inflicted head trauma. However, one of seven age matched control cases and one of 10 SIDS/sudden unexplained death in infancy (SUDI) cases demonstrated staining patterns similar to those seen in cases of inflicted trauma. We discuss these cases and the circumstances surrounding them with the intent to explain the difficulties associated with immunohistological interpretation of axonal injury. Although the utility of β APP is quite powerful if not confounded by global hypoxic ischemic injury, ultimately, β APP studies should be only one piece of information in the determination of cause and manner of death.
登录
查看更多内容
DOI：
10.1097/paf.0b013e31819df760
发表时间：
2009-12-01
影响因子：
1
作者：
Li, Ling;Zhang, Yang;Fowler, David R.
通讯作者：
Fowler, David R.
DOI：
10.1056/nejmra0803836
发表时间：
2009-08-20
期刊：
The New England journal of medicine
影响因子：
--
作者：
Kinney HC;Thach BT
通讯作者：
Thach BT
影响因子：
2.5
作者：
Sawaguchi, T;Patricia, F;Kahn, A
通讯作者：
Kahn, A
影响因子：
6.4
作者：
ADAMS, JH;DOYLE, D;MCLELLAN, DR
通讯作者：
MCLELLAN, DR
影响因子：
14.5
作者：
Geddes, JF;Hackshaw, AK;Whitwell, HL
通讯作者：
Whitwell, HL