Tumor self-seeding by circulating cancer cells.
Tumor self-seeding by circulating cancer cells.
复制标题
通过循环癌细胞自种肿瘤自种。
DOI：
10.1016/j.cell.2009.11.025
复制
发表时间：
2009-12-24
期刊：
影响因子：
64.5
通讯作者：
Massagué J
中科院分区：
文献类型：
--
作者：
Kim MY;Oskarsson T;Acharyya S;Nguyen DX;Zhang XH;Norton L;Massagué J
癌细胞从原发性肿瘤的传播通常被视为以远处器官的转移性定殖为高潮的单向过程。在这里，我们表明循环肿瘤细胞（CTC）也可以在我们称之为“肿瘤自我播种”的过程中定植于其起源的肿瘤。小鼠中乳腺癌、结肠癌和黑色素瘤肿瘤的自接种优先由侵袭性CTC介导，包括具有骨、肺或脑转移向性的那些。肿瘤源性细胞因子IL-6和IL-8作为CTC吸引剂，不良预后标志物MMP 1/胶原酶-1和肌动蛋白细胞骨架组分fascin-1作为CTC浸润到乳腺肿瘤中的介质。自接种可以通过种子衍生因子（包括乳腺癌模型中的趋化因子CXCL 1）加速肿瘤生长、血管生成和基质募集。肿瘤自身种植可以解释间变性、肿瘤大小、血管分布和预后之间的关系，以及表面上完全肿瘤切除后播散细胞种植的局部复发。
The dissemination of cancer cells from a primary tumor is conventionally viewed as a unidirectional process that culminates with the metastatic colonization of distant organs. Here we show that circulating tumor cells (CTCs) can also colonize their tumors of origin, in a process that we call “tumor self-seeding”. Self-seeding of breast cancer, colon cancer, and melanoma tumors in mice is preferentially mediated by aggressive CTCs, including those with bone, lung or brain metastatic tropism. The tumor-derived cytokines IL-6 and IL-8 acted as CTC attractants and the poor-prognosis markers MMP1/collagenase-1 and the actin cytoskeleton component fascin-1 as mediators of CTC infiltration into mammary tumors. Self-seeding can accelerate tumor growth, angiogenesis, and stromal recruitment through seed-derived factors including, in a breast cancer model, the chemokine CXCL1. Tumor self-seeding could explain the relationships between anaplasia, tumor size, vascularity and prognosis, and local recurrence seeded by disseminated cells following ostensibly complete tumor excision.
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DOI：
10.1111/j.1365-2613.2007.00539.x
发表时间：
2007-10-01
影响因子：
3
作者：
DuPre, Sally A.;Redelman, Doug;Hunter, Kenneth W., Jr.
通讯作者：
Hunter, Kenneth W., Jr.
影响因子：
4.8
作者：
Helbig, G;Christopherson, KW;Nakshatri, H
通讯作者：
Nakshatri, H
影响因子：
50.3
作者：
Kang, YB;Siegel, PM;Massagué, J
通讯作者：
Massagué, J
影响因子：
3.1
作者：
Kobayashi, Yoshiro
通讯作者：
Kobayashi, Yoshiro
影响因子：
50.3
作者：
Huesemann, Yves;Geigl, Jochen B.;Klein, Christoph A.
通讯作者：
Klein, Christoph A.