Brain structure and aging in chronic temporal lobe epilepsy.
Brain structure and aging in chronic temporal lobe epilepsy.
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DOI：
10.1111/j.1528-1167.2012.03447.x
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发表时间：
2012-06
期刊：
影响因子：
5.6
通讯作者：
Hermann B
中科院分区：
文献类型：
--
作者：
Dabbs K;Becker T;Jones J;Rutecki P;Seidenberg M;Hermann B
描述慢性儿童/青少年发作颞叶癫痫患者与健康对照组相比的脑结构差异及其年龄相关变化模式。受试者包括平均儿童/青少年发作的慢性颞叶癫痫患者（n= 55）和健康对照组（n=53），年龄14-60。使用FreeSurfer处理脑MRI（1.5T），以获得脑叶厚度、面积和体积以及各种皮质下结构和小脑体积的测量值。组间差异进行了探讨，然后通过横截面寿命建模作为年龄的函数。慢性颞叶癫痫患者的解剖学异常广泛，包括分布的皮质下结构（海马、丘脑、尾状核、苍白球）、小脑灰质和白色物质、全脑灰质和白色物质;以及颞叶（内侧、外侧）和颞外叶（额叶、顶叶）皮质灰质厚度、面积或体积的测量。对于癫痫患者和对照组，实际年龄的增加与不同皮质、皮质下和小脑区域的进行性变化相关。在选定的区域（第三脑室和侧脑室）观察到癫痫参与者的年龄加速变化，在其他感兴趣的区域中与年龄相关的变化模式基本相似。广泛的皮质，皮质下，和小脑异常存在于慢性儿童/青少年发作的颞叶癫痫的参与者，暗示一个显着的神经发育对大脑结构的影响。与健康对照组相比，随着年龄的增长，癫痫患者的大脑变化似乎以与年龄相适应的方式进行，主要例外是年龄加速的脑室扩张（侧脑室和第三脑室）。这些累积的结构异常似乎代表了癫痫患者的一个重要的解剖学负担，其后果仍有待确定，因为他们进入老年。
To characterize differences in brain structure and their patterns of age-related change in individuals with chronic childhood/adolescent onset temporal lobe epilepsy compared to healthy controls. Subjects included participants with chronic temporal lobe epilepsy (n= 55) of mean childhood/adolescent onset and healthy controls) (n=53), age 14–60. Brain MRIs (1.5T) were processed using FreeSurfer to obtain measures of lobar thickness, area and volume as well as volumes of diverse subcortical structures and cerebellum. Group differences were explored followed by cross-sectional lifespan modeling as a function of age. Anatomic abnormalities were extensive in participants with chronic temporal lobe epilepsy including distributed subcortical structures (hippocampus, thalamus, caudate, pallidum), cerebellar gray and white matter, total cerebral gray and white matter; and measures of cortical gray matter thickness, area or volume in temporal (medial, lateral) and extratemporal lobes (frontal, parietal). Increasing chronological age was associated with progressive changes in diverse cortical, subcortical and cerebellar regions for both participants with epilepsy and controls. Age accelerated changes in epilepsy participants were seen in selected areas (third and lateral ventricles), with largely comparable patterns of age-related change across other regions of interest. Extensive cortical, subcortical, and cerebellar abnormalities are present in participants with chronic childhood/adolescent onset temporal lobe epilepsy implicating a significant neurodevelopmental impact on brain structure. With increasing chronological age the brain changes occurring in epilepsy appear to proceed in an age-appropriate fashion compared to healthy controls, the primary exception being age-accelerated ventricular expansion (lateral and 3rd ventricles). These cumulative structural abnormalities appear to represent a significant anatomic burden for persons with epilepsy, the consequences of which remain to be determined as they progress into elder years.
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影响因子：
5.6
作者：
Bonilha L;Edwards JC;Kinsman SL;Morgan PS;Fridriksson J;Rorden C;Rumboldt Z;Roberts DR;Eckert MA;Halford JJ
通讯作者：
Halford JJ
影响因子：
5.7
作者：
Bernasconi, N;Duchesne, S;Bernasconi, A
通讯作者：
Bernasconi, A
影响因子：
11.2
作者：
Briellmann, RS;Berkovic, SF;Jackson, GD
通讯作者：
Jackson, GD
影响因子：
16.4
作者：
DODRILL, CB;MATTHEWS, CG
通讯作者：
MATTHEWS, CG
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI