Mrf4 (myf6) is dynamically expressed in differentiated zebrafish skeletal muscle.
Mrf4 (myf6) is dynamically expressed in differentiated zebrafish skeletal muscle.
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DOI：
10.1016/j.modgep.2007.06.003
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发表时间：
2007-08
影响因子：
1.2
通讯作者：
Hughes, Simon M.
中科院分区：
文献类型：
--
作者：
Hinits, Yaniv;Osborn, Daniel P. S.;Carvajal, Jaime J.;Rigby, Peter W. J.;Hughes, Simon M.
Mrf 4（Myf 6）是一个碱性螺旋-环-螺旋（bHLH）肌源性调节转录因子（MRF）家族，也包括Myod、Myf 5和肌细胞生成素。mrf 4与骨骼肌细胞的定向分化有关，并且在许多成人肌纤维中也大量表达。Mrf 4的具体作用尚不清楚，因为mrf 4缺失小鼠是可行的，表明与其他MRF冗余，并且因为复杂的mrf 4/myf 5基因座的遗传相互作用。我们报告了斑马鱼mrf 4基因的克隆和表达，该基因与myf 5连锁保守。Mrf 4 mRNA在躯干和鳍中与肌球蛋白平行地在终末分化的肌纤维的子集中积累。虽然大多数，可能是所有的躯干肌肉表达mrf 4，mRNA的水平是动态调节的。在肌球蛋白积聚之前，在肌肉前体细胞群中未检测到表达。此外，mrf 4的表达在头部肌肉中没有检测到，至少在早期阶段是这样。随着鱼的成熟，mrf 4在慢肌纤维中的表达是明显的。
Mrf4 (Myf6) is a basic helix-loop-helix (bHLH) myogenic regulatory transcription factor (MRF) family which also contains Myod, Myf5 and myogenin. Mrf4 is implicated in commitment of amniote cells to skeletal myogenesis and is also abundantly expressed in many adult muscle fibres. The specific role of Mrf4 is unclear both because mrf4 null mice are viable, suggesting redundancy with other MRFs, and because of genetic interactions at the complex mrf4/myf5 locus. We report the cloning and expression of an mrf4 gene from zebrafish, Danio rerio, which shows conservation of linkage to myf5. Mrf4 mRNA accumulates in a subset of terminally differentiated muscle fibres in parallel with myosin protein in the trunk and fin. Although most, possibly all, trunk muscle expresses mrf4, the level of mRNA is dynamically regulated. No expression is detected in muscle precursor cell populations prior to myosin accumulation. Moreover, mrf4 expression is not detected in head muscles, at least at early stages. As fish mature, mrf4 expression is pronounced in slow muscle fibres.
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影响因子：
2.7
作者：
FELSENFELD, AL;CURRY, M;KIMMEL, CB
通讯作者：
KIMMEL, CB
影响因子：
4.6
作者：
Hinits, Yaniv;Hughes, Simon M.
通讯作者：
Hughes, Simon M.
DOI：
10.1016/s0006-291x(02)02571-8
发表时间：
2002-11-22
影响因子：
3.1
作者：
Pin, CL;Konieczny, SF
通讯作者：
Konieczny, SF
影响因子：
2.7
作者：
Fomin, M;Nomokonova, N;Arnold, HH
通讯作者：
Arnold, HH
影响因子：
2.7
作者：
DANGOOR, M;SILBERSTEIN, L;MUHLRAD, A
通讯作者：
MUHLRAD, A