Early response of mouse joint tissue to noninvasive knee injury suggests treatment targets.

Early response of mouse joint tissue to noninvasive knee injury suggests treatment targets.
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小鼠关节组织对非侵入性膝关节损伤的早期反应提示了治疗目标

DOI:
10.1002/art.38375
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发表时间:
2014-05
影响因子:
13.3
通讯作者:
Sandell, L. J.
Sandell, L. J.
中科院分区:
医学1区
文献类型:
--
作者:
Wu, P.;Holguin, N.;Silva, M. J.;Fu, M.;Liao, W.;Sandell, L. J.

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关节创伤可导致一系列急性损害,包括软骨退化、韧带或半月板撕裂以及滑膜炎,所有这些都可能与骨关节炎(OA)相关。本研究旨在建立和验证在体非侵入性可控损伤压迫后的小鼠膝关节损伤模型。
Joint trauma can lead to a spectrum of acute lesions, including cartilage degradation, ligament or meniscus tears, and synovitis, all potentially associated with osteoarthritis (OA). This study was undertaken to generate and validate a murine model of knee joint trauma following noninvasive controlled injurious compression in vivo.
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