Different genetic basis for alcohol dehydrogenase activity and plasticity in a novel alcohol environment for Drosophila melanogaster
Different genetic basis for alcohol dehydrogenase activity and plasticity in a novel alcohol environment for Drosophila melanogaster
复制标题
黑腹果蝇新型酒精环境中乙醇脱氢酶活性和可塑性的不同遗传基础
DOI：
10.1038/s41437-020-0323-y
复制
发表时间：
2020
期刊：
影响因子：
3.8
通讯作者：
Althoff, David M.
中科院分区：
文献类型：
--
作者：
Wang, Sheng Pei;Althoff, David M.
表型可塑性被认为可以增强种群的持久性，促进适应性进化，并在新的环境中启动新的表型。可塑性如何促进或阻碍对不同环境的适应取决于其遗传结构。尽管许多性状的可塑性是由遗传控制的，但可塑性的遗传结构在新环境中是否会改变以及如何改变仍然不清楚。由于许多基因表达都可能受到环境的影响，因此每种环境都可能触发不同的基因组来影响一种性状。利用数量性状基因座（QTL）方法，我们研究了黑腹果蝇（D. melanogaster）乙醇脱氢酶（ADH）活性在历史和新的酒精环境中的遗传基础。先前对黑腹果蝇的研究也表明，ADH活性对成蝇和幼虫所用底物中的酒精浓度有可塑性反应。我们发现，在所有测试的环境中，ADH活性在很大程度上受到单个QTL的影响，该QTL包含Adh编码基因及其已知的调节位点delta-1。在控制了Adhand delta-1位点的等位变异后，我们在0和14%酒精环境中发现了额外的但不同的次要QTL。相比之下，我们发现没有主要的QTL可塑性本身，包括theAdh位点，无论环境梯度。这表明ADH活性的可塑性可能受到许多影响较小的位点的影响，并且Adh位点对饮食酒精不敏感。
Phenotypic plasticity is known to enhance population persistence, facilitate adaptive evolution and initiate novel phenotypes in novel environments. How plasticity can contribute or hinder adaptation to different environments hinges on its genetic architecture. Even though plasticity in many traits is genetically controlled, whether and how plasticity’s genetic architecture might change in novel environments is still unclear. Because much of gene expression can be environmentally influenced, each environment may trigger different sets of genes that influence a trait. Using a quantitative trait loci (QTL) approach, we investigated the genetic basis of plasticity in a classic functional trait, alcohol dehydrogenase (ADH) activity inD. melanogaster, across both historical and novel alcohol environments. Previous research inD. melanogasterhas also demonstrated that ADH activity is plastic in response to alcohol concentration in substrates used by both adult flies and larvae. We found that across all environments tested, ADH activity was largely influenced by a single QTL encompassing theAdh-coding gene and its known regulatory locus,delta-1. After controlling for the allelic variation of theAdhanddelta-1loci, we found additional but different minor QTLs in the 0 and 14% alcohol environments. In contrast, we discovered no major QTL for plasticity itself, including theAdhlocus, regardless of the environmental gradients. This suggests that plasticity in ADH activity is likely influenced by many loci with small effects, and that theAdhlocus is not environmentally sensitive to dietary alcohol.
登录
查看更多内容
影响因子：
2.7
作者：
GIBSON, JB;MAY, TW;WILKS, AV
通讯作者：
WILKS, AV
DOI：
10.2307/2419653
发表时间：
1998-05
期刊：
--
影响因子：
--
作者：
C. Schlichting;M. Pigliucci
通讯作者：
C. Schlichting;M. Pigliucci
影响因子：
7.7
作者：
Markow TA
通讯作者：
Markow TA
内含子多态性对果蝇乙醇脱氢酶表达的影响。
影响因子：
3.3
作者：
C. Laurie;L. F. Stam
通讯作者：
L. F. Stam
影响因子：
16.8
作者：
Levis, Nicholas A.;Isdaner, Andrew J.;Pfennig, David W.
通讯作者：
Pfennig, David W.