Prenatal maternal stress is associated with site-specific and age acceleration changes in maternal and newborn DNA methylation.
Prenatal maternal stress is associated with site-specific and age acceleration changes in maternal and newborn DNA methylation.
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DOI：
10.1080/15592294.2023.2222473
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发表时间：
2023-12
期刊：
影响因子：
3.7
通讯作者：
Mulligan, Connie J.
中科院分区：
文献类型：
--
作者：
Quinn, Edward B.;Hsiao, Chu J.;Maisha, Felicien M.;Mulligan, Connie J.
产前母亲压力对儿童健康有负面影响，但母亲压力影响儿童健康的机制尚不清楚。表观遗传变异，如DNA甲基化，是一个可能的机制候选人，因为DNA甲基化对环境损伤敏感，可以调节基因表达的长期变化。我们在刚果民主共和国招募了155对母亲-新生儿，以调查母亲压力对母亲和新生儿DNA甲基化的影响。我们使用了四种衡量母亲压力的方法来捕捉一系列压力经历：一般创伤、性创伤、战争创伤和慢性压力。我们确定了母亲和新生儿中与一般创伤、性创伤和战争创伤相关的差异甲基化位点（DMPs）。没有DMPs与慢性应激相关。在母亲的几个表观遗传时钟中，性创伤与表观遗传年龄加速呈正相关。一般创伤和战争创伤与新生儿表观遗传年龄加速呈正相关，使用外在表观遗传年龄钟。我们测试了DNA酶I超敏位点（DHS）富集的最佳DMP，发现母亲中没有富集。在新生儿中，与战争创伤相关的顶级DMP在胚胎和胎儿细胞类型中富集了DHS。最后，与新生儿战争创伤相关的最重要的DMPs之一也预测了出生体重，完成了从母亲压力到DNA甲基化再到新生儿健康结果的循环。我们的研究结果表明，母亲的压力是与特定地点的变化DNAm和表观遗传年龄加速在母亲和新生儿。
Prenatal maternal stress has a negative impact on child health but the mechanisms through which maternal stress affects child health are unclear. Epigenetic variation, such as DNA methylation, is a likely mechanistic candidate as DNA methylation is sensitive to environmental insults and can regulate long-term changes in gene expression. We recruited 155 mother-newborn dyads in the Democratic Republic of Congo to investigate the effects of maternal stress on DNA methylation in mothers and newborns. We used four measures of maternal stress to capture a range of stressful experiences: general trauma, sexual trauma, war trauma, and chronic stress. We identified differentially methylated positions (DMPs) associated with general trauma, sexual trauma, and war trauma in both mothers and newborns. No DMPs were associated with chronic stress. Sexual trauma was positively associated with epigenetic age acceleration across several epigenetic clocks in mothers. General trauma and war trauma were positively associated with newborn epigenetic age acceleration using the extrinsic epigenetic age clock. We tested the top DMPs for enrichment of DNase I hypersensitive sites (DHS) and found no enrichment in mothers. In newborns, top DMPs associated with war trauma were enriched for DHS in embryonic and foetal cell types. Finally, one of the top DMPs associated with war trauma in newborns also predicted birthweight, completing the cycle from maternal stress to DNA methylation to newborn health outcome. Our results indicate that maternal stress is associated with site-specific changes in DNAm and epigenetic age acceleration in both mothers and newborns.
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影响因子：
5.7
作者：
Haftorn KL;Lee Y;Denault WRP;Page CM;Nustad HE;Lyle R;Gjessing HK;Malmberg A;Magnus MC;Næss Ø;Czamara D;Räikkönen K;Lahti J;Magnus P;Håberg SE;Jugessur A;Bohlin J
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DOI：
10.1016/j.jpeds.2016.05.013
发表时间：
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期刊：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.1820838116
发表时间：
2020-09-22
影响因子：
11.1
作者：
Aristizabal, Maria J.;Anreiter, Ina;O'Donnell, Kieran J.
通讯作者：
O'Donnell, Kieran J.