BK virus and human cancer: innocent until proven guilty.
BK virus and human cancer: innocent until proven guilty.
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DOI：
10.1016/j.semcancer.2009.02.004
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发表时间：
2009-08
影响因子：
14.5
通讯作者：
Imperiale MJ
中科院分区：
文献类型：
--
作者：
Abend JR;Jiang M;Imperiale MJ
BK病毒（BKV）是一种广泛感染人类的多瘤病毒。在典型的亚临床原发性感染后，BKV在肾脏和尿路中建立终身持续感染。已知BKV在免疫抑制患者中重新激活并导致严重疾病，特别是肾和骨髓移植患者。啮齿动物模型或培养细胞中BKV的感染通常分别导致肿瘤形成或转化。当与活化的癌基因共表达时，BKV大肿瘤抗原驱动原代人细胞的转化。然而，BKV在人类癌症中的病因学作用仍然存在争议。多份报告已经证明了关于各种肿瘤类型中BKV序列和/或蛋白质的存在的相互矛盾的结果。本文综述了BKV检测在一些人类癌症中的最新发现。由于这些研究缺乏结论性的因果关系数据，BKV和人类癌症之间似乎没有明确的关联。
BK virus (BKV) is a polyomavirus that ubiquitously infects the human population. Following a typically subclinical primary infection, BKV establishes a lifelong persistent infection in the kidney and urinary tract. BKV is known to reactivate and cause severe disease in immunosuppressed patients, particularly renal and bone marrow transplant patients. Infection of BKV in rodent animal models or cells in culture often results in tumor formation or transformation, respectively. When co-expressed with activated oncogenes, BKV large tumor antigen drives the transformation of primary human cells. An etiological role of BKV in human cancer, however, remains controversial. Multiple reports have demonstrated conflicting results in regards to the presence of BKV sequences and/or proteins in various tumor types. This review compiles the most recent findings of BKV detection in a number of human cancers. Due to the lack of conclusive causality data from these studies, there does not appear to be a definitive association between BKV and human cancers.
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影响因子：
8
作者：
Catalano, A;Romano, M;Procopio, A
通讯作者：
Procopio, A
影响因子：
4.4
作者：
Bofill-Mas, S;Pina, S;Girones, R
通讯作者：
Girones, R
DOI：
10.1073/pnas.211026798
发表时间：
2001-10-09
影响因子：
11.1
作者：
Cacciotti, P;Libener, R;Gaudino, G
通讯作者：
Gaudino, G
影响因子：
6.4
作者：
BIRKELAND, SA;STORM, HH;PUKKALA, E
通讯作者：
PUKKALA, E
影响因子：
2.7
作者：
CORALLINI, A;ALTAVILLA, G;BARBANTIBRODANO, G
通讯作者：
BARBANTIBRODANO, G