Marrow B-cell precursors are increased in lymphomas or systemic diseases associated with B-cell dysfunction.
Marrow B-cell precursors are increased in lymphomas or systemic diseases associated with B-cell dysfunction.
复制标题
骨髓 B 细胞前体细胞在淋巴瘤或与 B 细胞功能障碍相关的全身性疾病中增加。
DOI：
10.1093/ajcp/100.1.60
复制
发表时间：
1993
影响因子：
3.5
通讯作者：
M. Borowitz
中科院分区：
文献类型：
--
作者：
A. M. Vandersteenhoven;J. Williams;M. Borowitz
已知骨髓再生与包括CD10+细胞在内的未成熟B细胞的增加有关。在一些罕见的细胞减少症儿童中也发现了类似的表型。本文描述了21例成人化疗后未恢复的患者，他们的骨髓CD10+细胞增加。流式细胞仪检测具有小淋巴细胞相对均匀的分散特性，多参数分析发现它们具有明显的表型，CD19+，缺乏表面免疫球蛋白，异质性表达CD20。在接受测试的三名患者中，有两名患者的早期B细胞中有一部分是TDT+，而不是全部。CD10+细胞占单个核细胞总数的10-76%。所有21名患者都有一些全身疾病。13例患者被诊断为淋巴瘤(3例霍奇金淋巴瘤，10例非霍奇金淋巴瘤)；后10例均为结外淋巴瘤，7例表型病例中7例为B细胞淋巴瘤。7名患者患有自身免疫性疾病(1名患者还患有淋巴瘤)，1名患者患有获得性免疫缺陷综合征合并骨髓分枝杆菌感染。1例有“病毒病”病史的患者有一个淋巴结伴生发中心进行性转化的不典型淋巴组织增生。这些患者的骨髓核心活检检查显示小淋巴细胞的增殖，从几乎看不到的弥漫性增加到大量的淋巴集合体。在两个骨髓中看到的广泛的淋巴细胞增多症提示仅在形态上诊断为淋巴瘤，但这些患者和任何其他患者都没有B细胞克隆性过剩。这种表型的存在表明，在免疫学或肿瘤性疾病中，骨髓B细胞前体的非特异性刺激与全身B细胞的激活有关。这种不寻常表型的出现并不意味着B细胞瘤累及骨髓。
Marrow regeneration is known to be associated with an increase in immature B cells, including CD10+ cells. A similar phenotype has been seen in some children with unusual cytopenias. This article describes 21 adult patients not recovering from chemotherapy, who had increased CD10+ cells in their marrows. These cells had the relatively uniform scatter properties of small lymphocytes by flow cytometry, and by multiparameter analysis were found to have a distinct phenotype in that they were CD19+, lacked surface immunoglobulin, and heterogeneity expressed CD20. In two of three patients tested, some but not all of these early B cells were TdT+. CD10+ cells accounted for 10-76% of total mononuclear cells. All 21 patients had some systemic illness. Thirteen patients had a diagnosis of lymphoma (three Hodgkin's, ten non-Hodgkin's); all ten of the latter were extranodal and seven of seven phenotyped cases were B-cell lymphomas. Seven patients had autoimmune disease (one also had lymphoma) and one had the acquired immunodeficiency syndrome with mycobacterial infection of the marrow. One patient with a history of a "viral illness" had a lymph node showing atypical lymphoid hyperplasia with progressive transformation of germinal centers. Examination of marrow core biopsies in these patients showed a proliferation of small lymphocytes ranging from a barely perceptible diffuse increase to numerous lymphoid aggregates. The extensive lymphocytosis seen in two marrows suggested a diagnosis of lymphoma on morphologic grounds alone, but neither these patients nor any others had B-cell clonal excess. The presence of this phenotype suggests nonspecific stimulation of marrow B-cell precursors associated with systemic B-cell activation in either an immunologic or neoplastic disorder. Presence of this unusual phenotype does not imply involvement of marrow by B-cell neoplasia.
登录
查看更多内容
影响因子：
20.3
作者：
M. Loken;V. O. Shah;Karen L. Dattilio;C. Civin
通讯作者：
M. Loken;V. O. Shah;Karen L. Dattilio;C. Civin
影响因子：
4.4
作者：
O. Martínez-Maza;E. Crabb;R. Mitsuyasu;J. Fahey;J. Giorgi
通讯作者：
O. Martínez-Maza;E. Crabb;R. Mitsuyasu;J. Fahey;J. Giorgi
通过造血分化抗原鉴定的正常骨髓中常见的急性淋巴细胞白血病抗原阳性淋巴细胞亚群。
影响因子：
20.3
作者：
Ryan,D;Kossover,S;Mitchell,S;Frantz,C;Hennessy,L;Cohen,H
通讯作者：
Cohen,H
周期性中性粒细胞减少症中外周血和骨髓淋巴细胞的循环。
DOI：
10.1073/pnas.80.18.5734
发表时间：
1983
影响因子：
11.1
作者：
Engelhard,D;Landreth,KS;Kapoor,N;Kincade,PW;DeBault,LE;Theodore,A;Good,RA
通讯作者：
Good,RA
B 细胞和 T 细胞谱系淋巴瘤表达常见急性淋巴细胞白血病抗原 (CALLA)。
影响因子：
20.3
作者：
Ritz,J;Nadler,LM;Bhan,AK;Notis-McConarty,J;Pesando,JM;Schlossman,SF
通讯作者：
Schlossman,SF