First Case Report of Fulminant Hepatitis After Laparoscopic Sleeve Gastrectomy Associated with Concomitant Maximal Therapeutic Dose of Acetaminophen Use, Protein Calorie Malnutrition, and Vitamins A and D, Selenium, and Glutathione Deficiencies.
First Case Report of Fulminant Hepatitis After Laparoscopic Sleeve Gastrectomy Associated with Concomitant Maximal Therapeutic Dose of Acetaminophen Use, Protein Calorie Malnutrition, and Vitamins A and D, Selenium, and Glutathione Deficiencies.
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DOI：
10.1007/s11695-020-04999-y
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发表时间：
2021-03
期刊：
影响因子：
2.9
通讯作者：
Elhag W
中科院分区：
文献类型：
--
作者：
Abusabeib A;El Ansari W;Alobaidan J;Elhag W
非酒精性脂肪性肝病(NAFLD)越来越多地与肥胖联系在一起。虽然腹腔镜袖状胃切除术(LSG)对最终治愈NAFLD的体重减轻是有效的，但在术后最初几个月可观察到一过性肝功能恶化，之后可能出现随后的肝功能改善。快速减肥、营养不足和蛋白质营养不良都可能导致肝功能障碍，并可能影响对乙酰氨基酚等药物的新陈代谢，导致对受损肝脏的更多伤害。我们报告LSG后的急性肝功能衰竭与蛋白质热量营养不良、多种营养缺乏以及同时使用治疗剂量的对乙酰氨基酚有关。使用N-乙酰半胱氨酸治疗，以及补充缺乏的多种维生素和微量元素，可显著改善肝功能。
Nonalcoholic fatty liver disease (NAFLD) is increasingly being linked to obesity. Although laparoscopic sleeve gastrectomy (LSG) is effective for weight loss that can ultimately resolve NAFLD, an initial transient deterioration of liver functions could be observed during the first few months post-operatively, after which a subsequent improvement of the liver functions might occur. Rapid weight loss, nutritional deficiencies, and protein malnutrition can all contribute to hepatic dysfunction and can affect the metabolism of medications such as acetaminophen leading to more insult to a compromised liver. We report acute liver failure after LSG associated with protein calorie malnutrition, multiple nutritional deficiencies in addition to concomitant use of therapeutic doses of acetaminophen. Treatment with N-acetylcysteine, and replacement of deficient multivitamins and trace elements resulted in significant improvement in liver functions.
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影响因子：
9
作者：
Kalinowski, Piotr;Paluszkiewicz, Rafal;Krawczyk, Marek
通讯作者：
Krawczyk, Marek
中国成人血浆硒水平与非酒精性脂肪肝：横断面分析。
影响因子：
4.6
作者：
Yang Z;Yan C;Liu G;Niu Y;Zhang W;Lu S;Li X;Zhang H;Ning G;Fan J;Qin L;Su Q
通讯作者：
Su Q
影响因子：
5.9
作者：
Saeed A;Dullaart RPF;Schreuder TCMA;Blokzijl H;Faber KN
通讯作者：
Faber KN
对乙酰氨基酚引起的肝毒性：全面更新。
影响因子：
3.6
作者：
Yoon E;Babar A;Choudhary M;Kutner M;Pyrsopoulos N
通讯作者：
Pyrsopoulos N
影响因子：
2.9
作者：
Caparrotta TM;Antoine DJ;Dear JW
通讯作者：
Dear JW