Adolescent alcohol exposure alters the central brain circuits known to regulate the stress response.
Adolescent alcohol exposure alters the central brain circuits known to regulate the stress response.
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DOI：
10.1016/j.neuroscience.2011.03.003
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发表时间：
2011-05-19
期刊：
影响因子：
3.3
通讯作者：
Lee SY
中科院分区：
文献类型：
--
作者：
Allen CD;Rivier CL;Lee SY
青少年酒精暴露（AAE）可能会对成年人的大脑产生长期影响。在这里，我们测试的假设，受影响的大脑区域包括大鼠下丘脑-垂体-肾上腺（HPA）轴。具体而言，我们研究了AAE [出生后（PND）28-42天]对成年早期（PND 61-62）灌胃（IG）酒精激发的雄性大鼠HPA轴相关脑回路的影响。青少年大鼠暴露于酒精蒸汽中，而对照组没有接受药物。产后第40天，青春期平均血液酒精水平为212.8 ± 5.7 mg %。采用免疫组织化学和原位杂交方法，我们测量了c-fos和促肾上腺皮质激素释放因子（CRF）在下丘脑室旁核（PVN）的信号，以及c-fos和苯乙醇胺N-甲基转移酶（PNMT）在肾上腺素能脑干区域（C1和C2）的信号。与对照组相比，PND 61-62检测的AAE大鼠PVN CRF mRNA表达显著减弱。这些动物还显示C2区中PNMT-ir细胞/脑干切片的平均数量显著增加。总的来说，这些结果表明，暴露于酒精蒸汽在青春期施加长期影响的PVN的能力，安装一个响应急性酒精管理在年轻的成年人，可能介导的延髓儿茶酚胺输入PVN。
Adolescent alcohol exposure (AAE) may exert long-term effects on the adult brain. Here, we tested the hypothesis that the brain regions affected include the rat hypothalamic-pituitary-adrenal (HPA) axis. Specifically, we examined the consequences of AAE [postnatal days (PND) 28–42] on the HPA axis-related brain circuitry of male rats challenged with an intragastric (ig) administration of alcohol in young adulthood (PND 61–62). Adolescent rats were exposed to alcohol vapors, while controls did not receive the drug. The mean blood alcohol level in adolescence on PND 40 was 212.8 ± 5.7 mg %. Using immunohistochemistry and in situ hybridization procedures, we measured signals for c-fos and corticotropin releasing factor (CRF) in the paraventricular nucleus (PVN) of the hypothalamus, as well as signals for c-fos and phenylethanolamine N-methyltransferase (PNMT) in the adrenergic brain stem regions (C1 and C2). PVN CRF mRNA expression was significantly blunted in AAE rats tested at PND 61–62, compared to their controls. These animals also displayed a significant increase in the mean number of PNMT-ir cells/brain stem section in the C2 area. Collectively, these results suggest that exposure to alcohol vapors during adolescence exerts long-term effects on the ability of the PVN to mount a response to an acute alcohol administration in young adulthood, possibly mediated by medullary catecholamine input to the PVN.
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影响因子：
4.8
作者：
Lee, S;Selvage, D;Rivier, C
通讯作者：
Rivier, C
影响因子：
3.7
作者：
Lee, S;Rivier, C
通讯作者：
Rivier, C
DOI：
10.1097/01.alc.0000179220.79356.e5
发表时间：
2005-09-01
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Barron, Susan;White, Aaron;Spear, Linda P
通讯作者：
Spear, Linda P
DOI：
10.1097/00000374-200101000-00014
发表时间：
2001-01-01
影响因子：
3.2
作者：
Lee, S;Schmidt, ED;Rivier, C
通讯作者：
Rivier, C
DOI：
10.1016/s0165-3806(97)00152-1
发表时间：
1998-01-14
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Dumas, TC;Foster, TC
通讯作者：
Foster, TC