Embryos assist morphogenesis of others through calcium and ATP signaling mechanisms in collective teratogen resistance.
Embryos assist morphogenesis of others through calcium and ATP signaling mechanisms in collective teratogen resistance.
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DOI：
10.1038/s41467-023-44522-2
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发表时间：
2024-01-17
影响因子：
16.6
通讯作者：
Levin, Michael
中科院分区：
文献类型：
--
作者：
Tung, Angela;Sperry, Megan M.;Clawson, Wesley;Pavuluri, Ananya;Bulatao, Sydney;Yue, Michelle;Flores, Ramses Martinez;Pai, Vaibhav P.;Mcmillen, Patrick;Kuchling, Franz;Levin, Michael
生物体模式的信息可以来自各种来源。我们研究了不仅在胚胎内的细胞水平上，而且还通过胚胎之间的相互作用提供对正常胚胎发育的指导性影响的可能性。为了探索这一点，我们用正常发育的干扰物挑战胚胎组，同时改变组的大小。在这里，我们表明，非洲爪蟾胚胎是更敏感的一组不同的化学和分子生物学扰动时，允许单独或在小团体，比在大团体。保持每个胚胎暴露恒定，我们发现增加队列中暴露胚胎的数量会增加存活率，而缺陷的发生率会降低。这种胚胎间辅助作用由短程可扩散信号介导，并涉及P2 ATP受体。我们的数据和计算模型强调，形态发生是一个集体现象，不仅在细胞水平，而且整个机构，和队列大小是一个至关重要的变量，在生态毒理学，致畸和发育可塑性的研究。细胞的集体活动使胚胎能够克服各种干扰。在这里，作者表明，在更高的（群体）水平上，胚胎也会交流。这使得更大的群体能够抵抗化学和分子遗传致畸剂。
Information for organismal patterning can come from a variety of sources. We investigate the possibility that instructive influences for normal embryonic development are provided not only at the level of cells within the embryo, but also via interactions between embryos. To explore this, we challenge groups of embryos with disruptors of normal development while varying group size. Here, we show that Xenopus laevis embryos are much more sensitive to a diverse set of chemical and molecular-biological perturbations when allowed to develop alone or in small groups, than in large groups. Keeping per-embryo exposure constant, we find that increasing the number of exposed embryos in a cohort increases the rate of survival while incidence of defects decreases. This inter-embryo assistance effect is mediated by short-range diffusible signals and involves the P2 ATP receptor. Our data and computational model emphasize that morphogenesis is a collective phenomenon not only at the level of cells, but also of whole bodies, and that cohort size is a crucial variable in studies of ecotoxicology, teratogenesis, and developmental plasticity. The collective activity of cells enables embryos to overcome various perturbations. Here, authors show that at the higher (population) level, embryos also communicate. This enables larger groups to resist chemical and molecular-genetic teratogens.
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影响因子：
3.3
作者：
BROMAN, H;BILOTTO, G;DE LUCA, CJ
通讯作者：
DE LUCA, CJ
影响因子：
2.6
作者：
BANTLE, JA;FORT, DJ;BUSH, SJ
通讯作者：
BUSH, SJ
影响因子：
1.6
作者：
Allee, WC;Schuett, JT
通讯作者：
Schuett, JT
DOI：
10.1016/s1472-9792(08)70028-3
发表时间：
2008-03-01
期刊：
Tuberculosis (Edinburgh, Scotland)
影响因子：
--
作者：
通讯作者：
--
影响因子：
7.3
作者：
BAILEY, SJ;HOURANI, SMO
通讯作者：
HOURANI, SMO