Association between serotonin transporter gene polymorphisms and increased suicidal risk among HIV positive patients in Uganda.
Association between serotonin transporter gene polymorphisms and increased suicidal risk among HIV positive patients in Uganda.
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DOI：
10.1186/s12863-017-0538-y
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发表时间：
2017-07-25
期刊：
影响因子：
2.9
通讯作者：
Kinyanda E
中科院分区：
文献类型：
--
作者：
Kalungi A;Seedat S;Hemmings SMJ;van der Merwe L;Joloba ML;Nanteza A;Nakassujja N;Birabwa H;Serwanga J;Kaleebu P;Kinyanda E
艾滋病毒/艾滋病感染者自杀的风险增加。自杀风险增加是未来自杀未遂和自杀未遂的预测因素，并与生活质量差和抗逆转录病毒治疗依从性差有关。临床危险因素对自杀的预测价值较低，因此对潜在的神经生物学相关性和自杀易感性的特定遗传标记感兴趣。5-羟色胺转运体基因先前已被牵连在非HIV感染的研究人群中自杀风险增加的病因学中，其变异可能为识别PLWHA中自杀的遗传风险提供平台。本横断面研究旨在确定两种常见的5-羟色胺转运体基因的遗传变异及其与乌干达人类免疫缺陷病毒（HIV）阳性成年人自杀风险增加的相关性。自杀风险增加的患病率（定义为简易神经精神访谈（M.I.N.I）自杀倾向模块中的中度至高风险自杀倾向）为3.3%（95% CI，2.0-5.3）。在Bonferroni校正前，发现5-HTTLPR与自杀风险增加相关（p值= 0.0174）。发现5-HTTLPR/rs 25531 SA等位基因对增加的自杀风险具有保护作用（p值= 0.0046）-其指导5-羟色胺转运蛋白基因（5-HTT）的表达降低。5-HTTLPR/rs 25531位点的SA等位基因与乌干达PLWHA中自杀风险增加相关。需要进一步的研究来验证乌干达和其他撒哈拉以南地区样本中的这一发现。
Persons living with HIV/AIDS (PLWHA) are at an increased risk of suicide. Increased suicidal risk is a predictor of future attempted and completed suicides and has been associated with poor quality of life and poor adherence with antiretroviral therapy. Clinical risk factors have low predictive value for suicide, hence the interest in potential neurobiological correlates and specific heritable markers of suicide vulnerability. The serotonin transporter gene has previously been implicated in the aetiology of increased suicidal risk in non-HIV infected study populations and its variations may provide a platform for identifying genetic risk for suicidality among PLWHA. The present cross-sectional study aimed at identifying two common genetic variants of the serotonin transporter gene and their association with increased suicidal risk among human immunodeficiency virus (HIV)-positive adults in Uganda. The prevalence of increased suicidal risk (defined as moderate to high risk suicidality on the suicidality module of the Mini Neuropsychiatric Interview (M.I.N.I) was 3.3% (95% CI, 2.0–5.3). The 5-HTTLPR was found to be associated with increased suicidal risk before Bonferroni correction (p-value = 0.0174). A protective effect on increased suicidal risk was found for the 5-HTTLPR/rs25531 S A allele (p-value = 0.0046)- which directs reduced expression of the serotonin transporter gene (5-HTT). The S A allele at the 5-HTTLPR/rs25531 locus is associated with increased suicidal risk among Ugandan PLWHA. Further studies are needed to validate this finding in Ugandan and other sub-Saharan samples.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1002/ajmg.b.31044
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发表时间：
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期刊：
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作者：
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