Evaluation of MRI models in the measurement of CMRO2 and its relationship with CBF.
Evaluation of MRI models in the measurement of CMRO2 and its relationship with CBF.
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DOI：
10.1002/mrm.21655
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发表时间：
2008-08
影响因子：
3.3
通讯作者：
Gao, Jia-Hong
中科院分区：
文献类型：
--
作者：
Lin, Ai-Ling;Fox, Peter T.;Yang, Yihong;Lu, Hanzhang;Tan, Li-Hai;Gao, Jia-Hong
本研究的目的是探讨不同的MRI生物物理模型在测量脑局部氧代谢率（CMRO 2）和脑血流量（CBF）在脑激活过程中的对应关系。通过同时测量视觉刺激过程中人视皮层中CBF、脑血容量（CBV）和血氧水平依赖（BOLD）MRI信号的相对变化来实现这一目的。放射状棋盘在五个不同的频率下提供闪光刺激。两个MRI模型，单室模型（SCM）和多室模型（MCM），被用来确定CMRO 2的相对变化，使用三种方法：[1] SCM与先前MRI研究中使用的参数相同（M = 0.22; α = 0.38）; [2]直接测量参数的SCM（M来自高碳酸血症，α来自测量的δCBV和δCBF）;和[3] MCM。用方法[2]和[3]得到的CMRO 2的相对变化幅度以及CBF和CMRO 2之间的非线性关系与用方法[1]得到的结果不一致。然而，方法[2]和[3]的结果与文献中的正电子发射断层扫描结果一致。我们的研究结果表明，如果使用适当的参数，SCM和MCM模型是等效的量化值CMRO 2和确定流量代谢关系。
The aim of this study was to investigate the various MRI biophysical models in the measurements of local cerebral metabolic rate of oxygen (CMRO2) and the corresponding relationship with cerebral blood flow (CBF) during brain activation. This aim was addressed by simultaneously measuring the relative changes in CBF, cerebral blood volume (CBV), and blood oxygen level dependent (BOLD) MRI signals in the human visual cortex during visual stimulation. A radial checkerboard delivered flash stimulation at five different frequencies. Two MRI models, the single-compartment model (SCM) and the multi-compartment model (MCM), were used to determine the relative changes in CMRO2 using three methods: [1] SCM with parameters identical to those used in a prior MRI study (M = 0.22; α = 0.38); [2] SCM with directly measured parameters (M from hypercapnia and α from measured δCBV and δCBF); and [3] MCM. The magnitude of relative changes in CMRO2 and the nonlinear relationship between CBF and CMRO2 obtained with Methods [2] and [3] were not in agreement with those obtained using Method [1]. However, the results of Methods [2] and [3] were aligned with positron emission tomography findings from the literature. Our results indicate that if appropriate parameters are used, the SCM and MCM models are equivalent for quantifying the values of CMRO2 and determining the flow-metabolism relationship.
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DOI：
10.1073/pnas.83.4.1140
发表时间：
1986-02-01
影响因子：
11.1
作者：
FOX, PT;RAICHLE, ME
通讯作者：
RAICHLE, ME
影响因子：
8.3
作者：
GRUBB, RL;RAICHLE, ME;TERPOGOS.MM
通讯作者：
TERPOGOS.MM
影响因子：
5.7
作者：
Chiarelli, Peter A.;Bulte, Daniel P.;Jezzard, Peter
通讯作者：
Jezzard, Peter
影响因子：
3.3
作者：
Lu, H;Golay, X;van Zijl, PCM
通讯作者：
van Zijl, PCM
影响因子：
3.3
作者：
Lu, HZ;Law, M;Helpern, JA
通讯作者：
Helpern, JA