Event-related potential indices of selective attention and cortical lateralization in schizophrenia.
Event-related potential indices of selective attention and cortical lateralization in schizophrenia.
复制标题
精神分裂症选择性注意和皮质偏侧化的事件相关电位指数。
作者：
Patricia T. Michie;Allison M. Fox;Philip B. Ward;S. Catts;N. McConaghy
对10例非药物治疗的精神分裂症患者和10例年龄、性别匹配的健康人进行了多维选择性注意任务的听觉事件相关电位(ERPs)检测。音调点音刺激在音高(高或低)和位置(左耳或右耳)上的不同形成了四个刺激通道：左低、左高、右低和右高。音调差异比位置差异更难区分。受试者被指示注意指定的频道，每当他们检测到在频繁的短持续时间标准音调中出现长持续时间的罕见目标音时，就按下按钮。未用药的精神分裂症患者和对照组在处理由标准音调引起的负面情绪方面有许多不同。在早期的负性加工成分中没有证据表明刺激维度的分层加工，而精神分裂症患者的晚期额叶成分几乎不存在。此外，有证据表明，精神分裂症患者对与目标具有相同音高的标准音调的位置维度的处理被延迟。精神分裂症患者在顶叶部位的P300成分显著减少，但在额叶部位两组之间没有差异。结果被解释为精神分裂症患者的多重注意缺陷，这表明选择性听力策略的计划和执行失败。这样的失败可能是由于大脑前额叶区域的功能障碍造成的。
Auditory event-related potentials (ERPs) from a multidimensional selective attention task were recorded from 10 unmedicated schizophrenic patients and 10 age- and sex-matched healthy controls. Tone pip stimuli varying on the dimensions of pitch (high or low) and location (left or right ear) formed four 'channels' of stimuli: left low, left high, right low, and right high. The pitch difference was considerably more difficult to discriminate than the location difference. Subjects were instructed to pay attention to a designated channel and press a button whenever they detected a long-duration, rare target tone that occurred amongst frequent short-duration standard tones. There were a number of differences between unmedicated schizophrenics and controls in processing negativity elicited by standard tones. There was no evidence of hierarchical processing of stimulus dimensions in the early processing negativity component, and the late frontal component was virtually absent in schizophrenics. Furthermore, there was evidence that in schizophrenics the processing of the location dimension was delayed for standard tones having the same pitch as the target. The P300 component to attended target tones was substantially reduced in schizophrenics over parietal sites but there was no difference between the two groups over frontal sites. The results are interpreted in terms of multiple attentional deficits in schizophrenics that are indicative of a failure in the planning and execution of selective listening strategies. Such a failure may result from a dysfunction in the prefrontal regions of the brain.
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DOI：
10.1037//0096-1523.9.1.1
发表时间：
1983-02
期刊：
Journal of experimental psychology. Human perception and performance
影响因子：
--
作者：
J. C. Hansen;S. Hillyard
通讯作者：
J. C. Hansen;S. Hillyard
DOI：
10.1016/0013-4694(81)91431-0
发表时间：
1981-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
KNIGHT, RT;HILLYARD, SA;NEVILLE, HJ
通讯作者：
NEVILLE, HJ
精神分裂症和情感患者在精神病发作期间和之后的连续回忆。
影响因子：
4.6
作者：
Frame,CL;Oltmanns,TF
通讯作者：
Oltmanns,TF
DOI：
10.1016/0013-4694(80)90222-9
发表时间：
1980-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
HANSEN, JC;HILLYARD, SA
通讯作者：
HILLYARD, SA