Associations between self-reported cannabis use frequency, potency, and cannabis/health metrics.
Associations between self-reported cannabis use frequency, potency, and cannabis/health metrics.
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DOI：
10.1016/j.drugpo.2021.103278
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Bidwell LC
中科院分区：
文献类型：
--
作者：
Steeger CM;Hitchcock LN;Bryan AD;Hutchison KE;Hill KG;Bidwell LC
研究表明，大麻使用频率与大麻依赖和健康指标有关。然而，关于自我报告的大麻效力(THC和CBD)如何与相同的指标相关联，以及在考虑大麻使用频率后是否存在任何关联，人们知道的要少得多。此外，更少人知道这些关系在不同的大麻产品形式上可能会有什么不同。这项探索性研究调查了1)大麻频率、效力和大麻/健康指标之间的关联，以及2)在控制频率后效力和大麻/健康指标之间的关联是否仍然存在。利用科罗拉多州(N=300)成年娱乐用大麻使用者的样本，我们测试了自我报告的大麻使用频率和效力指标与花、可食用和浓缩产品与问题大麻使用(即依赖、戒断、渴望)、抑郁、焦虑和总体健康的单独测量之间的关系。更频繁地使用鲜花和浓缩物(但不是可食用的)与更多有问题的大麻使用有关，更频繁地使用浓缩物也与更多的精神健康问题有关。控制所有产品形式的平均使用频率和每种产品的CBD效力的部分相关性表明，THC效力与大麻/健康指标之间仍然存在一个显著的关联(即，THC浓缩效力越高，健康状况越好)，并且出现了一个关联(即，更高的THC浓缩效力，更低的大麻戒断)。使用频率与花和浓缩物中有问题的大麻使用有可靠的联系，但它没有解释本研究中观察到的所有联系。不同大麻形式的频率和效力以及大麻/健康指标之间的关联模式的差异表明，需要更好地了解用户关于THC和CBD效力的报告、使用者之间的个体差异以及改进的衡量方法。
Research shows that cannabis use frequency is associated with cannabis dependence and health metrics. However, much less is known about how self-reported cannabis potency (THC and CBD) may be associated with the same metrics, and whether any associations exist after accounting for frequency of cannabis use. Moreover, even less is known about how these relations may differ across cannabis product forms. This exploratory study examined 1) associations between cannabis frequency, potency, and cannabis/health metrics, and 2) whether associations between potency and cannabis/health metrics remained after controlling for frequency. Using a sample of adult recreational cannabis users in Colorado (N=300), we tested the relationship between self-reported cannabis use metrics of frequency and potency of flower, edible, and concentrate products with separate measures of problematic cannabis use (i.e., dependence, withdrawal, craving), depression, anxiety, and general perceived health. Greater frequency of flower and concentrate (but not edible) use were associated with greater problematic cannabis use, and greater concentrate use frequency was also associated with more mental health problems. Partial correlations controlling for average frequency of use across all product forms and CBD potency per product showed that one significant association between THC potency and cannabis/health metrics remained (i.e., higher THC concentrate potency with better health), and one emerged (i.e., higher THC concentrate potency with lower cannabis withdrawal). Frequency of use is reliably associated with problematic cannabis use for flower and concentrates, but it did not account for all observed associations in this study. Differences in patterns of associations between frequency and potency and cannabis/health metrics across cannabis forms suggest a need for better understanding user reports of THC and CBD potency, individual differences among users, and improved measurement.
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