Lipid hypothesis of cardiovascular calcification.
Lipid hypothesis of cardiovascular calcification.
复制标题
心血管钙化的脂质假说。
DOI：
10.1161/01.cir.95.2.297
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发表时间：
1997
期刊：
影响因子：
37.8
通讯作者：
L. Demer
中科院分区：
文献类型：
--
作者：
L. Demer
人工心脏瓣膜钙化可能是一个毁灭性的事件，特别是在年幼的儿童。在本期《循环》杂志中，Vyavahare等1进行了重要观察，即用乙醇对瓣膜进行预处理可以防止生物心脏瓣膜钙化。这些发现不仅对心脏瓣膜病患者的治疗有直接影响，而且还提供了关于生物瓣膜钙化以及自体瓣膜疾病和动脉粥样硬化斑块的基本机制的线索。这项研究提出的一个特别重要的问题是脂质和/或蛋白质修饰是否是心血管钙化的病因因素。
为了解释乙醇对生物假体钙化的负面影响，Vyavahare及其同事1确定了三种可能的机制：磷脂和胆固醇的消除，胶原纤维构象的变化，以及乙醇对骨钙蛋白和/或钙化过程的可能直接影响。虽然它们为前两种可能性提供了证据，但以下分析表明，第一种机制占主导地位。
#脂质提取
尽管乙醇处理提取了几乎所有的脂质元素，但作者并不认为这是唯一的机制，因为脂质提取的替代方法氯仿-甲醇处理对钙化的影响小于乙醇，尽管提取更有效。然而，技术因素可能需要进一步考虑，因为其他使用氯仿-甲醇萃取的蒸馏器2 3 4在类似的...
Prosthetic heart valve calcification can be a devastating event, especially in young children. In this issue of Circulation, Vyavahare et al1 make the important observation that bioprosthetic heart valve calcification is prevented by valvular pretreatment with ethanol. Not only do these findings have a direct impact on treatment of patients with valvular heart disease, they also provide clues about the fundamental mechanisms underlying calcification of bioprosthetic valves as well as native valve disease and atherosclerotic plaque in general. A particularly important question raised by this study is whether lipids and/or protein modification is an etiologic factor in cardiovascular calcification.
To explain the negative effects of ethanol on bioprosthetic calcification, Vyavahare and colleagues1 identified three possible mechanisms: elimination of phospholipids and cholesterol, changes in collagen fiber conformation, and possible direct effects of ethanol on osteocalcin and/or the calcification process. Although they provide evidence for the first two possibilities, the following analysis suggests that the first mechanism predominates.
### Lipid Extraction
Although ethanol treatment extracted almost all the lipid elements, the authors did not consider this the sole mechanism because the alternative method of lipid extraction, chloroform-methanol treatment, had less effect on calcification than ethanol despite an even more effective extraction. However, technical factors may need to be considered further because other investigators2 3 4 using chloroform-methanol extraction in a similar …
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影响因子：
37.8
作者：
N. Vyavahare;D. Hirsch;E. Lerner;J. Baskin;F. Schoen;R. Bianco;H. Kruth;R. Zand;R. Levy
通讯作者：
N. Vyavahare;D. Hirsch;E. Lerner;J. Baskin;F. Schoen;R. Bianco;H. Kruth;R. Zand;R. Levy
影响因子：
15.9
作者：
BOSTROM, K;WATSON, KE;DEMER, LL
通讯作者：
DEMER, LL
DOI：
10.1161/01.atv.14.7.1151
发表时间：
1994-07-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
NIEVELSTEINPOST, P;MOTTINO, G;FRANK, J
通讯作者：
FRANK, J
影响因子：
15.9
作者：
WATSON, KE;BOSTROM, K;DEMER, LL
通讯作者：
DEMER, LL