Increasing the accuracy of electromagnetic inverses using functional area source correlation constraints.

Increasing the accuracy of electromagnetic inverses using functional area source correlation constraints.
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DOI:
10.1002/hbm.21394
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发表时间:
2012-11
影响因子:
4.8
通讯作者:
Norcia, Anthony M.
Norcia, Anthony M.
中科院分区:
医学2区
文献类型:
--
作者:
Cottereau, Benoit R.;Ales, Justin M.;Norcia, Anthony M.

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从脑电图(EEG)或脑磁图(MEG)数据估计皮层电流分布是一个困难的逆问题,其解可以通过添加相关神经响应的先验来改进。在视觉激活研究的背景下,我们提出了一种新的方法,使用功能区约束估计(FACE),以提高重建的准确性。它推导出源相关矩阵从皮层分割成由视网膜定位图的视野或功能定位独立获得的功能磁共振成像所定义的区域。对于每个个体受试者,这些面积计算一次,因此相关的估计量可以重新用于同一受试者的任何新研究。由此产生的FACE重建强调这些区域内的源的活动或加强它们的相互关联。我们使用现实的蒙特-卡罗模拟,以证明这种方法提高了我们的一组不同的源配置的估计。从一个真实的EEG数据集获得的重建表明,我们的先验提高了水平视差处理中涉及的皮层区域的本地化。
Estimating cortical current distributions from electroencephalographic (EEG) or magnetoencephalographic (MEG) data is a difficult inverse problem whose solution can be improved by the addition of priors on the associated neural responses. In the context of visual activation studies, we propose a new approach that uses a functional area constrained estimator (FACE) to increase the accuracy of the reconstructions. It derives the source correlation matrix from a segmentation of the cortex into areas defined by retinotopic maps of the visual field or by functional localizers obtained independently by fMRI. These areas are computed once for each individual subject and the associated estimators can therefore be re-used for any new study on the same participant. The resulting FACE reconstructions emphasize the activity of sources within these areas or enforce their inter-correlations. We used realistic Monte-Carlo simulations to demonstrate that this approach improved our estimates of a diverse set of source configurations. Reconstructions obtained from a real EEG dataset demonstrate that our priors improve the localization of the cortical areas involved in horizontal disparity processing.
定位人类主要视觉皮层的功能和解剖边界。
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