Locating the functional and anatomical boundaries of human primary visual cortex.
Locating the functional and anatomical boundaries of human primary visual cortex.
复制标题
定位人类主要视觉皮层的功能和解剖边界。
DOI：
10.1016/j.neuroimage.2009.03.036
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发表时间：
2009-07-15
期刊：
影响因子：
5.7
通讯作者：
Triantafyllou C
中科院分区：
文献类型：
--
作者：
Hinds O;Polimeni JR;Rajendran N;Balasubramanian M;Amunts K;Zilles K;Schwartz EL;Fischl B;Triantafyllou C
初级视皮层(V1)既可以通过其视野地形图在功能上描绘出来，也可以通过其独特的板层髓鞘形成模式在解剖上描绘出来。虽然人们普遍认为V1的特殊解剖结构在位置上与功能定义的V1相对应，但由于很难确定V1在同一个体中的功能和解剖位置，迄今还不可能在人类中证明这一点。在这项研究中，我们使用MRI测量同一个体的解剖和功能V1的边界，并证明它们之间非常一致。根据功能磁共振测量的视野地形图，将10名活人的枕叶皮质划分为视觉皮质区域，以测量功能V1的位置。使用10个完整的体外人类大脑半球的Gennari纹的高分辨率结构MRI得到的基于表面的概率图谱，对这些受试者的V1解剖位置进行了估计。为了确保图谱的预测是正确的，它与V1位置进行了验证，该V1位置是使用独立于观察者的皮质切片测量的，该切片基于来自10个独立个体的连续脑切片中细胞密度的层状模式。独立的解剖和功能衍生的V1边界之间的密切一致表明，根据结构MRI扫描计算的皮质表面重建，可以准确预测V1的整个范围，从而消除了对V1功能定位器的需要。此外，初级皮质褶皱预测了功能性V1的位置，这表明引起V1位置的机制与皮质褶皱的发育有关。
The primary visual cortex (V1) can be delineated both functionally by its topographic map of the visual field and anatomically by its distinct pattern of laminar myelination. Although it is commonly assumed that the specialized anatomy V1 exhibits corresponds in location with functionally defined V1, demonstrating this in human has not been possible thus far due to the difficulty of determining the location of V1 both functionally and anatomically in the same individual. In this study we use MRI to measure the anatomical and functional V1 boundaries in the same individual and demonstrate close agreement between them. Functional V1 location was measured by parcellating occipital cortex of 10 living humans into visual cortical areas based on the topographic map of the visual field measured using functional MRI. Anatomical V1 location was estimated for these same subjects using a surface-based probabilistic atlas derived from high-resolution structural MRI of the stria of Gennari in 10 intact ex vivo human hemispheres. To ensure that the atlas prediction was correct, it was validated against V1 location measured using an observer-independent cortical parcellation based on the laminar pattern of cell density in serial brain sections from 10 separate individuals. The close agreement between the independent anatomically and functionally derived V1 boundaries indicates that the whole extent of V1 can be accurately predicted based on cortical surface reconstructions computed from structural MRI scans, eliminating the need for functional localizers of V1. In addition, that the primary cortical folds predict the location of functional V1 suggests that the mechanism giving rise to V1 location is tied to the development of the cortical folds.
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5.7
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