Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy.
Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy.
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DOI：
10.1371/journal.pone.0201371
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
STAR Network Investigators
中科院分区：
文献类型：
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作者：
Ostuzzi G;Mazzi MA;Terlizzi S;Bertolini F;Aguglia A;Bartoli F;Bortolaso P;Callegari C;Caroleo M;Carrà G;Corbo M;D'Agostino A;Gastaldon C;Lucii C;Magliocco F;Martinotti G;Nosé M;Ostinelli EG;Papola D;Piccinelli MP;Piccoli A;Purgato M;Tabacchi T;Turrini G;Ruggeri M;Barbui C;STAR Network Investigators
多年来，长效肌注（LAI）抗精神病药物主要用于慢性病和重症患者，作为其他治疗失败时的最后手段。最近，人们强调更广泛和更早地使用 LAI，特别是第二代 LAI。迄今为止，很少有研究试图阐明这种处方变化在现实世界实践中是如何发生的。因此，本研究旨在描述接受 LAI 治疗的患者的临床特征，并探讨意大利普通临床实践中第一代和第二代 LAI 之间可能存在的处方差异。 STAR Network“Depot”研究是一项观察性、纵向、多中心研究，涉及意大利 35 个中心。在横断面阶段，连续招募接受 LAI 治疗的患者并在 12 个月的时间内进行评估。采用描述性统计和多变量逻辑回归分析。在 451 名招募的患者中，61% 是男性。社会和工作功能水平存在差异，疾病的严重程度也是如此。 72% 的患者被诊断为精神分裂症谱系。 70% 的患者服用了第二代抗精神病药 (SGA) LAI（主要是帕潘立酮、阿立哌唑和利培酮）。与第一代抗精神病药物 (FGA) LAI 相比，服用 SGA LAI 的患者往往更年轻；受雇；诊断为精神分裂症谱系或双相情感障碍；具有较高程度的情感症状；过去 LAI 处方较少。与过去相比，LAI 的处方做法似乎更加灵活，尽管这种变化主要限于 SGA LAI。
For many years, long-acting intramuscular (LAI) antipsychotics have been prescribed predominantly to chronic and severe patients, as a last resort when other treatments failed. Recently, a broader and earlier use of LAIs, particularly second-generation LAIs, has been emphasized. To date, few studies attempted to frame how this change in prescribing took place in real-world practice. Therefore, this study aimed to describe the clinical features of patients prescribed with LAIs, and to explore possible prescribing differences between first- and second-generations LAIs under ordinary clinical practice in Italy. The STAR Network “Depot” Study is an observational, longitudinal, multicenter study involving 35 centers in Italy. In the cross-sectional phase, patients prescribed with LAIs were consecutively recruited and assessed over a period of 12 months. Descriptive statistics and multivariable logistic regression analyses were employed. Of the 451 recruited patients, 61% were males. The level of social and working functioning was heterogeneous, as was the severity of disease. Seventy-two per cent of the patients had a diagnosis of the schizophrenia spectrum. Seventy per cent were prescribed with second-generation antipsychotic (SGA) LAIs (mostly paliperidone, aripiprazole and risperidone). Compared to first-generation antipsychotic (FGA) LAIs, patients prescribed with SGA LAIs were more often younger; employed; with a diagnosis of the schizophrenia spectrum or bipolar disorder; with higher levels of affective symptoms; with fewer LAI prescriptions in the past. LAIs’ prescribing practices appear to be more flexible as compared to the past, although this change is mostly restricted to SGA LAIs.
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影响因子：
3.2
作者：
De Risio, Alessandro;Lang, Antonella P.
通讯作者：
Lang, Antonella P.
影响因子：
4.2
作者：
Das, Amlan K.;Malik, Abid;Haddad, Peter M.
通讯作者：
Haddad, Peter M.
影响因子：
2.9
作者：
Cipriani, Andrea;Accordini, Simone;Barbui, Corrado
通讯作者：
Barbui, Corrado
影响因子：
--
作者：
Gaviria, Ana M;Franco, Jose;Vilella, Elisabet
通讯作者：
Vilella, Elisabet
影响因子：
3.7
作者：
Decuypere F;Sermon J;Geerts P;Denee TR;De Vos C;Malfait B;Lamotte M;Mulder CL
通讯作者：
Mulder CL