The relationship between metabolic syndrome and asthma in the elderly.
The relationship between metabolic syndrome and asthma in the elderly.
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DOI：
10.1038/s41598-018-26621-z
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发表时间：
2018-06-20
影响因子：
4.6
通讯作者：
Lee CH
中科院分区：
文献类型：
--
作者：
Park S;Choi NK;Kim S;Lee CH
老年人的哮喘负担在增加，但老年人哮喘的病因尚不清楚。最近的研究报告了代谢综合征(MS)和哮喘之间的流行病学联系，但很少在老年人中进行研究。这项研究调查了MS和哮喘之间的关系，以及胰岛素抵抗(IR)和全身炎症在老年MS-哮喘相关性中的作用。我们的研究分析了4,060名老年参与者(≥65岁)，他们来自一项横断面调查，即2007年至2012年韩国国民健康和营养检查调查。进行中介分析以检查胰岛素抵抗和全身性炎症是否调节MS-哮喘的关联。患有多发性硬化症的参与者哮喘患病率显著升高(调整后的优势比 = 为1.34；95%可信区间 = 为1.09-1.64)，腰围较大、高密度脂蛋白胆固醇水平较低的人群尤其容易发生哮喘。IR和全身炎症的参与者与较高的哮喘患病率相关。患有多发性硬化症或每种多发性硬化症的参与者的IR和全身炎症的患病率较高。胰岛素抵抗和全身炎症在很大程度上介导了MS-哮喘的相关性。我们的研究表明多发性硬化症与老年人哮喘之间存在显著的相关性。MS可能通过IR和全身炎症影响哮喘。
The burden of asthma in the elderly is increasing, but the etiology of asthma in the elderly is not clearly understood. Recent studies have reported the epidemiological link between metabolic syndrome (MS) and asthma, but it has rarely been studied in the elderly. This study investigated the association between MS and asthma and the contribution of insulin resistance (IR) and systemic inflammation to this MS-asthma association in the elderly. Our study analyzed 4,060 elderly participants (≥65 years old) from a cross-sectional survey, the Korean National Health and Nutritional Examination Survey 2007–2012. Mediation analyses were performed to examine whether IR and systemic inflammation mediates the MS-asthma association. Participants with MS had significantly higher prevalence of asthma (adjusted odds ratio = 1.34; 95% confidence interval = 1.09–1.64), and those who had greater waist circumference and lower HDL-C were especially likely to have asthma. Participants with IR and systemic inflammation were associated with higher prevalence of asthma. Prevalence of IR and systemic inflammation were higher in participants with MS or with each MS component. The MS-asthma association was substantially mediated by IR and systemic inflammation. Our study showed a significant association between MS and asthma in the elderly. MS might affect asthma through both IR and systemic inflammation.
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DOI：
10.1016/j.jaci.2011.06.048
发表时间：
2011-09
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Hanania NA;King MJ;Braman SS;Saltoun C;Wise RA;Enright P;Falsey AR;Mathur SK;Ramsdell JW;Rogers L;Stempel DA;Lima JJ;Fish JE;Wilson SR;Boyd C;Patel KV;Irvin CG;Yawn BP;Halm EA;Wasserman SI;Sands MF;Ershler WB;Ledford DK;Asthma in Elderly workshop participants
通讯作者：
Asthma in Elderly workshop participants
影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
影响因子：
1.6
作者：
Denys, K.;Cankurtaran, M.;Petrovic, M.
通讯作者：
Petrovic, M.
DOI：
10.1164/rccm.201303-0457oc
发表时间：
2013-08-01
影响因子：
24.7
作者：
Assad, Nour;Qualls, Clifford;Sood, Akshay
通讯作者：
Sood, Akshay
影响因子：
4.3
作者：
Parameswaran, K;Hildreth, AJ;Bansal, SK
通讯作者：
Bansal, SK