Kv4.2 mediates histamine modulation of preoptic neuron activity and body temperature.
Kv4.2 mediates histamine modulation of preoptic neuron activity and body temperature.
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DOI：
10.1371/journal.pone.0029134
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Tabarean IV
中科院分区：
文献类型：
--
作者：
Sethi J;Sanchez-Alavez M;Tabarean IV
Histamine regulates arousal, circadian rhythms, and thermoregulation. Activation of H3 histamine receptors expressed by preoptic GABAergic neurons results in a decrease of their firing rate and hyperthermia. Here we report that an increase in the A-type K+ current in preoptic GABAergic neurons in response to activation of H3 histamine receptors results in decreased firing rate and hyperthermia in mice. The Kv4.2 subunit is required for these actions in spite of the fact that Kv4.2−/− preoptic GABAergic neurons display A-type currents and firing characteristics similar to those of wild-type neurons. This electrical remodeling is achieved by robust upregulation of the expression of the Kv4.1 subunit and of a delayed rectifier current. Dynamic clamp experiments indicate that enhancement of the A-type current by a similar amount to that induced by histamine is sufficient to mimic its robust effect on firing rates. These data indicate a central role played by the Kv4.2 subunit in histamine regulation of body temperature and its interaction with pERK1/2 downstream of the H3 receptor. We also reveal that this pathway provides a mechanism for selective modulation of body temperature at the beginning of the active phase of the circadian cycle.
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DOI：
10.1016/0165-1838(92)90050-q
发表时间：
1992-06-15
期刊：
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
影响因子：
--
作者：
PRAST, H;DIETL, H;PHILIPPU, A
通讯作者：
PHILIPPU, A
影响因子：
4.1
作者：
Abrahamson, Eric E.;Moore, Robert Y.
通讯作者：
Moore, Robert Y.
DOI：
10.1523/jneurosci.2237-08.2008
发表时间：
2008-10-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Khaliq ZM;Bean BP
通讯作者：
Bean BP
影响因子：
5.3
作者：
Bourdeau, Mathieu L.;Morin, France;Lacaille, Jean-Claude
通讯作者：
Lacaille, Jean-Claude
影响因子：
2.5
作者：
Hu, HJ;Glauner, KS;Gereau, RW
通讯作者：
Gereau, RW