Prognostic significance of dysadherin expression in advanced colorectal carcinoma.
Prognostic significance of dysadherin expression in advanced colorectal carcinoma.
复制标题
DOI：
10.1038/sj.bjc.6600778
复制
发表时间：
2003-03-10
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
粘附素是一种新型的糖蛋白，它通过下调E-钙粘附素的表达而发挥抗细胞黏附的作用。本研究检测了82例II、III期结直肠癌组织中粘附素和E-钙粘附素的表达，以探讨它们与肿瘤临床病理特征的关系。在正常大肠上皮中未见Dys粘附素的表达。51%的肿瘤在超过50%的癌细胞中显示粘附素免疫阳性。38%的肿瘤显示E-钙粘素免疫阳性降低。粘附素表达增高与肺转移显著相关(P=0.003)。粘附素表达增加对患者生存率有显著影响(P=0.0099和0.0036，总生存率和无复发生存率的对数等级检验)。此外，粘附素表达增加和E-钙粘附素表达降低的肿瘤预后最差(总生存率和无复发生存率的对数等级检验分别为P=0.0043和0.0028)。这些结果表明，粘附素表达增加是晚期结直肠癌患者预后不良的一个重要指标。
A novel glycoprotein, dysadherin, has an anti-cell – cell adhesion function through downregulating E-cadherin. In this study, we investigated the expressions of dysadherin and E-cadherin in 82 patients with stage II and III colorectal carcinomas to determine the correlation between the two molecules and the clinicopathologic features of each tumour. Dysadherin was not expressed in normal colorectal epithelium. Fifty-one per cent of tumours showed dysadherin immunopositivity in over 50% of cancer cells. Thirty-eight per cent of tumours showed reduced E-cadherin immunopositivity. The increased expression of dysadherin was significantly associated with lung metastasis (P=0.003). The increased expression of dysadherin had a significant impact on patient survival (P=0.0099 and 0.0036, log-rank test for overall and recurrence-free survival rate, respectively). Furthermore, tumour with increased expression of dysadherin and reduced expression of E-cadherin showed the worst prognosis (P=0.0043 and 0.0028, log-rank test for overall and recurrence-free survival rate, respectively). These results suggest that increased dysadherin expression is a significant indicator of poor prognosis for patients with advanced colorectal carcinoma.
登录
查看更多内容
影响因子：
8.8
作者：
KATAGIRI, A;WATANABE, R;TOMITA, Y
通讯作者：
TOMITA, Y
影响因子：
3.5
作者：
Saito, M;Yamaguchi, A;Furukawa, K
通讯作者：
Furukawa, K
DOI：
10.1073/pnas.012425299
发表时间：
2002-01-08
影响因子：
11.1
作者：
Ino, Y;Gotoh, M;Hirohashi, S
通讯作者：
Hirohashi, S
影响因子：
8.8
作者：
Dorudi, S;Hanby, A M;Poulsom, R;Northover, J;Hart, I R
通讯作者：
Hart, I R
DOI：
10.1083/jcb.108.6.2435
发表时间：
1989-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Behrens J;Mareel MM;Van Roy FM;Birchmeier W
通讯作者：
Birchmeier W