Linking context with reward: a functional circuit from hippocampal CA3 to ventral tegmental area.
Linking context with reward: a functional circuit from hippocampal CA3 to ventral tegmental area.
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DOI：
10.1126/science.1204622
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发表时间：
2011-07-15
期刊：
影响因子：
--
通讯作者：
Aston-Jones G
中科院分区：
文献类型：
--
作者：
Luo AH;Tahsili-Fahadan P;Wise RA;Lupica CR;Aston-Jones G
奖励动机行为强烈地受到环境中情境刺激的学习意义的影响。然而，调节情境-奖励关系的神经通路还没有得到很好的理解。我们已经确定了从背侧海马CA 3区到腹侧被盖区（VTA）的回路，该回路使用外侧隔（LS）作为中继。θ频率刺激CA 3可兴奋腹侧被盖区多巴胺（DA）神经元，抑制非DA神经元。DA神经元的兴奋可能是由去抑制介导的，因为γ-氨基丁酸受体的局部拮抗作用阻断了对CA 3刺激的反应。CA 3-LS-VTA通路的失活成分阻断了VTA的诱发反应，也阻断了背景刺激对可卡因寻求的恢复。海马和腹侧被盖区之间的这种跨突触联系似乎是环境背景调节目标导向行为的重要底物。
Reward-motivated behavior is strongly influenced by the learned significance of contextual stimuli in the environment. However, the neural pathways that mediate context-reward relations are not well understood. We have identified a circuit from area CA3 of dorsal hippocampus to ventral tegmental area (VTA) that uses lateral septum (LS) as a relay. Theta frequency stimulation of CA3 excited VTA dopamine (DA) neurons and inhibited non-DA neurons. DA neuron excitation was likely mediated by disinhibition because local antagonism of γ-aminobutyric acid receptors blocked responses to CA3 stimulation. Inactivating components of the CA3-LS-VTA pathway blocked evoked responses in VTA and also reinstatement of cocaine-seeking by contextual stimuli. This transsynaptic link between hippocampus and VTA appears to be an important substrate by which environmental context regulates goal-directed behavior.
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