Type I interferons as regulators of human antigen presenting cell functions.
Type I interferons as regulators of human antigen presenting cell functions.
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DOI：
10.3390/toxins6061696
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发表时间：
2014-05-26
期刊：
影响因子：
4.2
通讯作者：
Belardelli F
中科院分区：
文献类型：
--
作者：
Gessani S;Conti L;Del Cornò M;Belardelli F
I型干扰素（IFN）是多效性细胞因子，最初因其抗病毒活性而被描述。这些细胞因子在患有某些类型的癌症、病毒感染和慢性炎性疾病的患者中表现出长期的临床使用记录。现在已经确定IFN的作用主要依赖于它们调节宿主先天性和适应性免疫应答的能力。近年来的工作已经开始阐明I型IFN修饰免疫应答的机制，现在认为这是由于对多种细胞类型的影响，包括单核细胞、树突细胞（DC）、NK细胞、T和B淋巴细胞。动物模型和体外研究的结果都强调了I型IFN在DC的发育和功能中的关键作用，表明这些细胞因子和DC之间存在天然联盟，将先天性免疫与获得性免疫联系起来。因此，鉴定DC中的IFN特征及其在病理条件下的失调对于破译这种DC-IFN相互作用的复杂性和更好地利用这些细胞的治疗潜力将是关键的。
Type I interferons (IFNs) are pleiotropic cytokines, initially described for their antiviral activity. These cytokines exhibit a long record of clinical use in patients with some types of cancer, viral infections and chronic inflammatory diseases. It is now well established that IFN action mostly relies on their ability to modulate host innate and adaptive immune responses. Work in recent years has begun to elucidate the mechanisms by which type I IFNs modify the immune response, and this is now recognized to be due to effects on multiple cell types, including monocytes, dendritic cells (DCs), NK cells, T and B lymphocytes. An ensemble of results from both animal models and in vitro studies emphasized the key role of type I IFNs in the development and function of DCs, suggesting the existence of a natural alliance between these cytokines and DCs in linking innate to adaptive immunity. The identification of IFN signatures in DCs and their dysregulation under pathological conditions will therefore be pivotal to decipher the complexity of this DC-IFN interaction and to better exploit the therapeutic potential of these cells.
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影响因子：
3.8
作者：
Carbonneil, C;Aouba, A;Weiss, L
通讯作者：
Weiss, L
DOI：
10.1084/jem.20112343
发表时间：
2012-04-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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影响因子：
3.5
作者：
Chen, Ting;Li, Zhoubin;Zhu, Jianhua
通讯作者：
Zhu, Jianhua
影响因子：
6.2
作者：
Bracci, Laura;La Sorsa, Valentina;Proietti, Enrico
通讯作者：
Proietti, Enrico
影响因子：
3.9
作者：
Bracci, Laura;Schumacher, Reto;Spagnoli, Giulio C.
通讯作者：
Spagnoli, Giulio C.