Age-specific incidence rates for dementia and Alzheimer disease in NIA-LOAD/NCRAD and EFIGA families: National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) and Estudio Familiar de Influencia Genetica en Alzhei
Age-specific incidence rates for dementia and Alzheimer disease in NIA-LOAD/NCRAD and EFIGA families: National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) and Estudio Familiar de Influencia Genetica en Alzhei
复制标题
NIA-LOAD/NCRAD 和 EFIGA 家族中痴呆症和阿尔茨海默病的年龄特异性发病率：国家晚发阿尔茨海默病衰老遗传学研究所/国家阿尔茨海默病细胞存储库 (NIA-LOAD/NCRAD) 和 Estudio Familiar de
作者：
B. Vardarajan;K. Faber;T. Bird;D. Bennett;R. Rosenberg;B. Boeve;N. Graff;A. Goate;M. Farlow;R. Sweet;R. Lantigua;M. Medrano;R. Ottman;D. Schaid;T. Foroud;R. Mayeux
重要性
晚发性阿尔茨海默病 (LOAD) 定义为 65 岁后出现症状，是最常见的痴呆症。很少有报告调查大型家庭研究中的发病率，其中参与者是根据 LOAD 家族史选择的。
目标
旨在确定国家晚发性阿尔茨海默病衰老遗传学研究所/国家阿尔茨海默病细胞存储库 (NIA-LOAD/NCRAD) 和阿尔茨海默病遗传流行病研究所 (EFIGA) 家族研究中未受影响成员的痴呆症和 LOAD 发病率。
设计、场景和参与者
作为 NIA-LOAD/NCRAD 家庭研究的一部分，招募有 2 个或更多受影响兄弟姐妹且临床或病理诊断为 LOAD 的家庭。作为 EFIGA 研究的一部分，纽约 Taub 阿尔茨海默病和大脑老化研究所以及多米尼加共和国诊所的另一项研究招募了一组患有家族性 LOAD 的加勒比西班牙裔人群。
主要成果和措施
NIA-LOAD/NCRAD 和 EFIGA 数据集中未受影响的家庭成员中估计了 LOAD 的年龄特定发病率。我们将分析限制在具有后续和完整表型信息的家族中，包括 396 个 NIA-LOAD/NCRAD 家族和 242 个 EFIGA 家族。在 NIA-LOAD/NCRAD 家庭的 943 名高危家庭成员中，126 人（13.4%）患有痴呆症，其中 109 人（86.5%）符合 LOAD 标准。在 EFIGA 家庭的 683 名高危家庭成员中，174 人（25.5%）在研究期间出现痴呆，其中 145 人（83.3%）患有 LOAD。
结果
NIA-LOAD/NCRAD 家庭中 65 至 74 岁参与者的痴呆和 LOAD 年发病率每人年分别为 0.03 和 0.03； 75岁至84岁的人分别为0.07和0.06； 85 岁或以上的人分别为 0.08 和 0.07。 EFIGA家庭的发病率略高，在同一年龄组中分别为0.03和0.02、0.06和0.05、0.10和0.08、0.10和0.07。将这些结果与基于人群的估计结果进行对比，与 NIA-LOAD/NCRAD 家族相比，NIA-LOAD/NCRAD 家族的发病率增加了 3 倍（标准化发病率，3.44），而 EFIGA 的发病率则比 NIA-LOAD/NCRAD 家族增加了 2 倍（1.71）。
结论和相关性
NIA-LOAD/NCRAD 和 EFIGA 家庭中家族性痴呆和 LOAD 的发病率显着高于基于人群的估计。所有群体的发病率随着年龄的增长而增加。 LOAD 发病率较高可以通过这些家族中阿尔茨海默病相关基因的分离或共同的环境风险来解释。
IMPORTANCE
Late-onset Alzheimer disease (LOAD), defined as onset of symptoms after age 65 years, is the most common form of dementia. Few reports investigate incidence rates in large family-based studies in which the participants were selected for family history of LOAD.
OBJECTIVE
To determine the incidence rates of dementia and LOAD in unaffected members in the National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) and Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA) family studies.
DESIGN, SETTING, AND PARTICIPANTS
Families with 2 or more affected siblings who had a clinical or pathological diagnosis of LOAD were recruited as a part of the NIA-LOAD/NCRAD Family Study. A cohort of Caribbean Hispanics with familial LOAD was recruited in a different study at the Taub Institute for Research on Alzheimer's Disease and the Aging Brain in New York and from clinics in the Dominican Republic as part of the EFIGA study.
MAIN OUTCOMES AND MEASURES
Age-specific incidence rates of LOAD were estimated in the unaffected family members in the NIA-LOAD/NCRAD and EFIGA data sets. We restricted analyses to families with follow-up and complete phenotype information, including 396 NIA-LOAD/NCRAD and 242 EFIGA families. Among the 943 at-risk family members in the NIA-LOAD/NCRAD families, 126 (13.4%) developed dementia, of whom 109 (86.5%) met criteria for LOAD. Among 683 at-risk family members in the EFIGA families, 174 (25.5%) developed dementia during the study period, of whom 145 (83.3%) had LOAD.
RESULTS
The annual incidence rates of dementia and LOAD in the NIA-LOAD/NCRAD families per person-year were 0.03 and 0.03, respectively, in participants aged 65 to 74 years; 0.07 and 0.06, respectively, in those aged 75 to 84 years; and 0.08 and 0.07, respectively, in those 85 years or older. Incidence rates in the EFIGA families were slightly higher, at 0.03 and 0.02, 0.06 and 0.05, 0.10 and 0.08, and 0.10 and 0.07, respectively, in the same age groups. Contrasting these results with the population-based estimates, the incidence was increased by 3-fold for NIA-LOAD/NCRAD families (standardized incidence ratio, 3.44) and 2-fold among the EFIGA compared with the NIA-LOAD/NCRAD families (1.71).
CONCLUSIONS AND RELEVANCE
The incidence rates for familial dementia and LOAD in the NIA-LOAD/NCRAD and EFIGA families are significantly higher than population-based estimates. The incidence rates in all groups increase with age. The higher incidence of LOAD can be explained by segregation of Alzheimer disease-related genes in these families or shared environmental risks.
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DOI：
10.1001/jama.1994.03510370056032
发表时间：
1994-04
期刊：
JAMA
影响因子：
--
作者：
Y. Stern;B. Gurland;T. Tatemichi;M. Tang;D. Wilder;R. Mayeux
通讯作者：
Y. Stern;B. Gurland;T. Tatemichi;M. Tang;D. Wilder;R. Mayeux
影响因子：
6.5
作者：
J. Hixson;D. T. Vernier
通讯作者：
J. Hixson;D. T. Vernier
影响因子：
120.7
作者：
Green, RC;Cupples, LA;Farrer, LA
通讯作者：
Farrer, LA
DOI：
10.1001/jama.1995.03520410048025
发表时间：
1995-05
期刊：
JAMA
影响因子：
--
作者：
L. Hebert;P. Scherr;Laurel A. Beckett;M. Albert;D. Pilgrim;Marilyn J. Chown;H. Funkenstein;Denis A. Evans
通讯作者：
L. Hebert;P. Scherr;Laurel A. Beckett;M. Albert;D. Pilgrim;Marilyn J. Chown;H. Funkenstein;Denis A. Evans
影响因子：
12.7
作者：
Brookmeyer, R;Gray, S;Kawas, C
通讯作者：
Kawas, C