PRRs are watching you: Localization of innate sensing and signaling regulators.
PRRs are watching you: Localization of innate sensing and signaling regulators.
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DOI：
10.1016/j.virol.2015.02.051
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发表时间：
2015-05
期刊：
影响因子：
3.7
通讯作者：
Kagan, Jonathan C.
中科院分区：
文献类型：
--
作者：
Chow, Jonathan;Franz, Kate M.;Kagan, Jonathan C.
为了防止感染的传播，入侵的病原体必须首先被先天免疫系统识别。宿主模式识别受体检测不同的病原体相关分子，并诱导干扰素和炎症分子的转录和释放以解决感染。与从宿主自主复制的病原体感染不同，病毒感染模糊了自我和非我的界限。宿主和病毒的区别是通过限制宿主核酸的定位和将模式识别受体放置在特定的亚细胞隔间来实现的。在这篇综述中，我们讨论了几个模式识别受体家族如何作用于提供一个全面的监测网络，该网络具有诱导干扰素表达的潜力，以应对任何病毒感染。
To prevent the spread of infection, an invading pathogen must first be recognized by the innate immune system. Host pattern recognition receptors detect distinct pathogen-associated molecules and induce the transcription and release of interferon and inflammatory molecules to resolve infection. Unlike infections with pathogens that replicate autonomously from the host, viral infections blur the boundaries of self and non-self. Differentiation of host from virus is achieved by restricting localization of host nucleic acids and by placing pattern recognition receptors in specific subcellular compartments. Within this review, we discuss how several families of pattern recognition receptors act to provide a comprehensive surveillance network that has the potential to induce interferon expression in response to any viral infection.
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影响因子：
64.8
作者：
通讯作者：
--
通过RIG-I介导的5'-二磷酸RNA识别的抗病毒药免疫。
影响因子：
64.8
作者：
Goubau, Delphine;Schlee, Martin;Deddouche, Safia;Pruijssers, Andrea J.;Zillinger, Thomas;Goldeck, Marion;Schuberth, Christine;Van der Veen, Annemarthe G.;Fujimura, Tsutomu;Rehwinkel, Jan;Iskarpatyoti, Jason A.;Barchet, Winfried;Ludwig, Janos;Dermody, Terence S.;Hartmann, Gunther;Reis e Sousa, Caetano
通讯作者：
Reis e Sousa, Caetano
影响因子：
64.5
作者：
Dixit E;Boulant S;Zhang Y;Lee AS;Odendall C;Shum B;Hacohen N;Chen ZJ;Whelan SP;Fransen M;Nibert ML;Superti-Furga G;Kagan JC
通讯作者：
Kagan JC
影响因子：
64.8
作者：
Alexopoulou, L;Holt, AC;Flavell, RA
通讯作者：
Flavell, RA
影响因子：
3.7
作者：
CAIRNS, J
通讯作者：
CAIRNS, J