Regulation of nucleocytoplasmic trafficking of viral proteins: an integral role in pathogenesis?
Regulation of nucleocytoplasmic trafficking of viral proteins: an integral role in pathogenesis?
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DOI：
10.1016/j.bbamcr.2011.03.019
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发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
Jans DA
中科院分区：
文献类型：
--
作者：
Fulcher AJ;Jans DA
蛋白质进出核的信号依赖性靶向由转运受体的输入蛋白（IMP）家族成员介导，其识别货物蛋白内的靶向信号并介导通过核内包埋的核孔复合物。这一过程的调节对于细胞分裂和分化等过程至关重要，但对于病毒复制和发病机制也至关重要;磷酸化似乎在调节病毒蛋白质核质运输沿着其他翻译后修饰中起主要作用。这篇评论的重点是病毒蛋白，利用宿主细胞IMP机械，以交通进入/出的核，特别是那些贩运是至关重要的病毒复制和/或发病机制，如猿猴病毒SV 40大肿瘤抗原（T-ag），人乳头瘤病毒E1蛋白，人巨细胞病毒持续合成因子ppUL 44，和各种基因产物的RNA病毒，如狂犬病。了解调节病毒蛋白质核质运输的机制对于未来迫切需要的特异性和有效的抗病毒治疗的发展至关重要。这篇文章最初是为特刊“通过调节核蛋白输入来调节信号和细胞命运”准备的。出版商对由此造成的不便表示歉意。病毒蛋白质的核质运输是病毒感染的核心。翻译后修饰是调控病毒蛋白运输的重要手段。病毒蛋白的核运输可以成为开发抗病毒药物的目标。
Signal-dependent targeting of proteins into and out of the nucleus is mediated by members of the importin (IMP) family of transport receptors, which recognise targeting signals within a cargo protein and mediate passage through the nuclear envelope-embedded nuclear pore complexes. Regulation of this process is paramount to processes such as cell division and differentiation, but is also critically important for viral replication and pathogenesis; phosphorylation appears to play a major role in regulating viral protein nucleocytoplasmic trafficking, along with other posttranslational modifications. This review focuses on viral proteins that utilise the host cell IMP machinery in order to traffic into/out of the nucleus, and in particular those where trafficking is critical to viral replication and/or pathogenesis, such as simian virus SV40 large tumour antigen (T-ag), human papilloma virus E1 protein, human cytomegalovirus processivity factor ppUL44, and various gene products from RNA viruses such as Rabies. Understanding of the mechanisms regulating viral protein nucleocytoplasmic trafficking is paramount to the future development of urgently needed specific and effective anti-viral therapeutics. This article was originally intended for the special issue “Regulation of Signaling and Cellular Fate through Modulation of Nuclear Protein Import”. The Publisher apologizes for any inconvenience caused. ► Nucleocytoplasmic trafficking of viral proteins is central to viral infection. ► Posttranslational modification is a key means to regulate viral protein trafficking. ► Nuclear trafficking of viral proteins can be a target for development of anti-virals.
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DOI：
10.1073/pnas.87.12.4766
发表时间：
1990-06-01
影响因子：
11.1
作者：
BISCHOFF, JR;FRIEDMAN, PN;BEACH, D
通讯作者：
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影响因子：
5.4
作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
5.4
作者：
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通讯作者：
FRISQUE, RJ
DOI：
10.1016/j.str.2009.07.014
发表时间：
2009-09-09
期刊：
Structure (London, England : 1993)
影响因子：
--
作者：
Brohawn SG;Partridge JR;Whittle JR;Schwartz TU
通讯作者：
Schwartz TU