Influences of five dietary manganese sources on growth, feed utilization, lipid metabolism, antioxidant capacity, inflammatory response and endoplasmic reticulum stress in yellow catfish intestine
Influences of five dietary manganese sources on growth, feed utilization, lipid metabolism, antioxidant capacity, inflammatory response and endoplasmic reticulum stress in yellow catfish intestine
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五种膳食锰源对黄颡鱼肠道生长、饲料利用率、脂质代谢、抗氧化能力、炎症反应和内质网应激的影响
DOI：
10.1016/j.aquaculture.2022.739190
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发表时间：
2023-03
期刊：
影响因子：
4.5
通讯作者：
Zhi Luo
中科院分区：
文献类型：
--
作者：
Jie-Jie Xu;Bing-Yu Jia;Tao Zhao;Xiao-Ying Tan;Dian-Guang Zhang;Chang-Chun Song;Yu-Feng Song;Ester Zito;Zhi Luo
研究了5种锰源对黄颡鱼生长、饲料利用、脂质代谢、抗氧化能力、肠道炎症反应和内质网应激的影响。五种锰源包括一水硫酸锰（MnSO 4·H2O）、二氧化锰（MnO 2）、二氧化锰纳米颗粒（MnO 2NPs）、甘氨酸螯合锰（Mn-Gly）和羟甲硫氨酸螯合锰（Mn-MHA）。黄颡鱼（初始体重：2.69 ± 0.01g/尾）饲喂5种试验饲料10周。饲粮锰源显著影响肠道锰含量和代谢。与其他锰源相比，黄颡鱼饲喂有机锰源（Mn-Gly和Mn-MHA）有助于改善生长、饲料利用、肠道组织学，上调紧密连接相关基因的mRNA丰度，增加肠道脂肪酸的摄取和转运以及甘油三酯沉积，并减少炎症反应。这些膳食有机锰补充剂还通过上调抗氧化基因表达和酶活性来增加肠道抗氧化能力。两种有机锰饲料均降低了黄颡鱼内质网应激相关基因和蛋白的表达。根据上述观察，膳食有机补充剂（Mn-Gly和Mn-MHA）提高了黄颡鱼的生长和饲料利用率，促进了肠道健康，因此是黄颡鱼的最佳锰源。内质网应激和脂肪酸的吸收和吸收，发现有机锰源更适合作为黄颡鱼饲料中的锰补充剂，也可能在其他水产饲料中。
The present study was conducted to evaluate the influences of five dietary manganese (Mn) sources on growth, feed utilization, lipid metabolism, antioxidant capacity, inflammatory response and endoplasmic reticulum stress in intestinal tissues of yellow catfishPelteobagrusfulvidraco. Five Mn sources include Mn sulfate monohydrate (MnSO4·H2O), Mn dioxide (MnO2), Mn dioxide nanoparticles (MnO2NPs), Mn glycine chelate (Mn-Gly) and hydroxymethionine-chelated Mn (Mn-MHA). Yellow catfish (initial body weight: 2.69 ± 0.01 g/fish) were fed five experimental diets for 10 weeks. Dietary Mn sources significantly affected intestinal Mn content and metabolism. Compared to other Mn sources, yellow catfish fed organic Mn sources (Mn-Gly and Mn-MHA) tended to improve growth, feed utilization, intestinal histology, up-regulated mRNA abundance of tight junction-relevant genes, increased intestinal fatty acid uptake and transport and triglyceride deposition, and reduced inflammatory responses. These dietary organic Mn supplements also increased intestinal antioxidant capacity by up-regulating antioxidant gene expression and enzymatic activities. Yellow catfish fed two organic Mn diets had the lower mRNA expressions of endoplasmic reticulum stress-relevant gene and protein expression. Based on these observations above, dietary organic supplements (Mn-Gly and Mn-MHA) improved the growth and feed utilization, and promoted intestinal health of yellow catfish, and accordingly seems to be optimal Mn sources for yellow catfish.Statement of relevanceOur results provided the innovative insights into dietary Mn sources influencing tight junction, antioxidant capacity and inflammatory responses, endoplasmic reticulum stress and fatty acid uptake and uptake in the fish intestine, and found that organic Mn sources were more suitable as the Mn supplements in yellow catfish feeds, and also possibly in other aquatic feed.
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