Differential Expression of Non-Coding RNAs in Stem Cell Development and Therapeutics of Bone Disorders.
Differential Expression of Non-Coding RNAs in Stem Cell Development and Therapeutics of Bone Disorders.
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干细胞的自我更新和多谱系分化受到信号因子、染色质调节因子、转录因子和非编码 RNA (ncRNA) 组成的复杂网络的调节。最近发现了 ncRNA 在干细胞发育和骨稳态维持中的多种作用。 ncRNA，如长链非编码RNA、微小RNA、环状RNA、小干扰RNA、Piwi相互作用RNA等，不翻译成蛋白质，而是在干细胞的自我更新和分化中充当重要的表观遗传调节因子。 ncRNA 的差异表达可有效监测不同的信号通路，ncRNA 作为决定干细胞命运的调节元件。此外，几种ncRNA可以作为骨疾病早期诊断的潜在分子生物标志物，包括骨质疏松症、骨关节炎和骨癌，最终导致新治疗策略的开发。本文旨在探讨ncRNA在干细胞生长发育、成骨细胞和破骨细胞活性调节中的具体作用及其有效分子机制。此外，我们关注并探索 ncRNA 表达改变与干细胞和骨转换的关联。
Stem cells’ self-renewal and multi-lineage differentiation are regulated by a complex network consisting of signaling factors, chromatin regulators, transcription factors, and non-coding RNAs (ncRNAs). Diverse role of ncRNAs in stem cell development and maintenance of bone homeostasis have been discovered recently. The ncRNAs, such as long non-coding RNAs, micro RNAs, circular RNAs, small interfering RNA, Piwi-interacting RNAs, etc., are not translated into proteins but act as essential epigenetic regulators in stem cells’ self-renewal and differentiation. Different signaling pathways are monitored efficiently by the differential expression of ncRNAs, which function as regulatory elements in determining the fate of stem cells. In addition, several species of ncRNAs could serve as potential molecular biomarkers in early diagnosis of bone diseases, including osteoporosis, osteoarthritis, and bone cancers, ultimately leading to the development of new therapeutic strategies. This review aims to explore the specific roles of ncRNAs and their effective molecular mechanisms in the growth and development of stem cells, and in the regulation of osteoblast and osteoclast activities. Furthermore, we focus on and explore the association of altered ncRNA expression with stem cells and bone turnover.
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DOI：
10.1016/j.jconrel.2015.07.030
发表时间：
2015-12-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Batrakova EV;Kim MS
通讯作者：
Kim MS
lncRNA 多态性与骨矿物质密度的全基因组关联研究。
影响因子：
1.9
作者：
Zeng Q;Wu KH;Liu K;Hu Y;Chen XD;Zhang L;Shen H;Tian Q;Zhao LJ;Deng HW;Tan LJ
通讯作者：
Tan LJ
影响因子：
2.4
作者：
Bhaskaran M;Mohan M
通讯作者：
Mohan M
影响因子：
4
作者：
Cao, Guijun;Meng, Xianqing;Li, Jinhua
通讯作者：
Li, Jinhua
DOI：
10.18632/oncoscience.421
发表时间：
2018-05
期刊：
Oncoscience
影响因子：
--
作者：
Behera J;Tyagi N
通讯作者：
Tyagi N