Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis.
Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis.
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DOI：
10.1016/j.fertnstert.2010.11.036
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发表时间：
2011-03-01
影响因子：
6.7
通讯作者：
Gonzalez, Frank
中科院分区：
文献类型：
--
作者：
Escobar-Morreale, Hector F.;Luque-Ramirez, Manuel;Gonzalez, Frank
回顾和荟萃分析评估多囊卵巢综合征 (PCOS) 女性血清炎症标志物状态的研究。对 2010 年 1 月之前发表的英文文章进行系统回顾和荟萃分析，并使用 Entrez-PubMed 引擎进行识别。学术医院通过高灵敏度技术测量炎症标志物的血清浓度。对 PCOS 患者和适当对照之间血清 C 反应蛋白 (CRP)、白细胞介素 6 (IL-6) 和肿瘤坏死因子 α (TNF-α) 浓度的平均差异进行荟萃分析，应用随机效应模型来限制研究间变异性，并使用证据传播偏倚的适当估计。对符合纳入标准的 31 篇文章的荟萃分析显示，与对照组相比，PCOS 女性的循环 CRP 高 96%（95% 置信区间 71% – 122%，z = 7.32，p < 0.0001），且不存在证据传播偏差（Egger 回归截距 0.45，95% 置信区间 -2.30 – 3.21，P = 0.739）。在排除五项多囊卵巢综合症女性和对照组女性体重和/或肥胖频率不匹配的研究后，这些发现仍然存在。涉及 10 项 IL-6 研究和 9 项 TNF-α 研究的荟萃分析显示，PCOS 和对照组之间没有统计学上的显着差异。患有 PCOS 的女性表现出与肥胖无关的循环 CRP 升高。这一发现证实了慢性低度炎症的现有分子证据，该炎症可能是这种疾病的发病机制。
To review and meta-analyse the studies evaluating the status of serum inflammatory markers in women with Polycystic Ovary Syndrome (PCOS). Systematic review and meta-analysis of articles published in English before January 2010 and identified using the Entrez-PubMed engine. Academic hospital Measurement of serum concentrations of inflammatory markers by high-sensitivity techniques. Meta-analyses of the mean difference in serum C-reactive protein (CRP), interlekin-6 (IL-6) and tumor necrosis factor-α (TNF-α) concentrations among patients with PCOS and appropriate controls, applying random-effects models to limit interstudy variability, and using appropriate estimates of evidence dissemination bias. Meta-analysis of the 31 articles meeting inclusion criteria showed that circulating CRP was 96% higher in women with PCOS compared to controls (95% confidence interval 71% – 122%, z = 7.32, p < 0.0001) without evidence dissemination bias (Egger’s regression intercept 0.45, 95% confidence interval −2.30 – 3.21, P = 0.739). These findings persisted after excluding five studies with mismatches in body mass and/or frequency of obesity between women with PCOS and controls. Meta-analyses involving 10 studies of IL-6, and 9 studies of TNF-α revealed no statistically significant differences between PCOS and controls. Women with PCOS exhibit elevation in circulating CRP that is independent of obesity. This finding corroborates existing molecular evidence of the chronic low-grade inflammation that may underpin the pathogenesis of this disorder.
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影响因子：
3.7
作者：
Alvarez-Blasco F;Martínez-García MA;Luque-Ramírez M;Parraza N;San Millán JL;Escobar-Morreale HF
通讯作者：
Escobar-Morreale HF
影响因子：
6.7
作者：
Arikan, Senay;Akay, Hatice;Gokalp, Deniz
通讯作者：
Gokalp, Deniz
影响因子：
--
作者：
Bahceci, M;Tuzcu, A;Aslan, C
通讯作者：
Aslan, C
影响因子：
5.8
作者：
Boulman, N;Levy, Y;Blumenfeld, Z
通讯作者：
Blumenfeld, Z
影响因子：
5.8
作者：
Bastard, JP;Jardel, C;Hainque, B
通讯作者：
Hainque, B