Emerging functions for the Staphylococcus aureus RNome.

Emerging functions for the Staphylococcus aureus RNome.
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DOI:
10.1371/journal.ppat.1003767
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发表时间:
2013
期刊:
影响因子:
6.7
通讯作者:
Felden B
Felden B
中科院分区:
医学1区
文献类型:
--
作者:
Guillet J;Hallier M;Felden B

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金黄色葡萄球菌是动物和人类的主要病原体,不仅是医院相关感染中最常见的分离细菌之一,而且还会在社区引起疾病。为了协调其众多毒力基因的表达与生长和生存,金黄色葡萄球菌使用各种信号通路,包括双组分调控系统、转录因子和大约250个调控RNA。只有少数这些sRNA的生物学作用被确定,包括顺式、反式和顺式反式作用的RNA,一些在内部编码小的功能多肽,另一些具有双重或多重功能。在这里,我们提出了这些迷人的sRNA的清单;参与它们活动的蛋白质;以及那些参与应激反应、新陈代谢和毒力的蛋白质。
Staphylococcus aureus is a leading pathogen for animals and humans, not only being one of the most frequently isolated bacteria in hospital-associated infections but also causing diseases in the community. To coordinate the expression of its numerous virulence genes for growth and survival, S. aureus uses various signalling pathways that include two-component regulatory systems, transcription factors, and also around 250 regulatory RNAs. Biological roles have only been determined for a handful of these sRNAs, including cis, trans, and cis-trans acting RNAs, some internally encoding small, functional peptides and others possessing dual or multiple functions. Here we put forward an inventory of these fascinating sRNAs; the proteins involved in their activities; and those involved in stress response, metabolisms, and virulence.
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