Thresholding of auditory cortical representation by background noise.
Thresholding of auditory cortical representation by background noise.
复制标题
背景噪声对听觉皮层表征的阈值
DOI：
10.3389/fncir.2014.00133
复制
发表时间：
2014
影响因子：
3.5
通讯作者：
Xiao Z
中科院分区：
文献类型：
--
作者：
Liang F;Bai L;Tao HW;Zhang LI;Xiao Z
一般认为背景噪音会掩盖听觉信息。然而，噪声如何以一种水平依赖的方式特异性地改变神经元听觉处理仍有待仔细确定。在本研究中，我们利用大鼠初级听觉皮层（A1）第4层的活体松散贴片细胞记录，系统地研究了不同水平的连续宽带噪声如何影响单个神经元的感受野特性。我们发现，当背景噪声超过一定的临界/有效水平时，会导致音调诱发反应的强度阈值升高。阈值的增加与临界水平以上的噪声强度呈线性关系。因此，单个神经元的音调感受野（TRF）作为一个整体沿着强度域向上翻译为高强度。这使得首选特征频率（CF）和后机匣的整体形状得以保留，但减少了频率响应范围，并增强了对相同刺激强度的频率选择性。在兴奋性和快速尖峰抑制性神经元以及单调和非单调（强度调节）A1神经元中均观察到这种对强度阈值的翻译效应。我们的研究结果表明，在噪声背景下，基本听觉表征通过背景电平相关的沿强度域的线性移位进行调制，这相当于降低刺激强度。
It is generally thought that background noise can mask auditory information. However, how the noise specifically transforms neuronal auditory processing in a level-dependent manner remains to be carefully determined. Here, with in vivo loose-patch cell-attached recordings in layer 4 of the rat primary auditory cortex (A1), we systematically examined how continuous wideband noise of different levels affected receptive field properties of individual neurons. We found that the background noise, when above a certain critical/effective level, resulted in an elevation of intensity threshold for tone-evoked responses. This increase of threshold was linearly dependent on the noise intensity above the critical level. As such, the tonal receptive field (TRF) of individual neurons was translated upward as an entirety toward high intensities along the intensity domain. This resulted in preserved preferred characteristic frequency (CF) and the overall shape of TRF, but reduced frequency responding range and an enhanced frequency selectivity for the same stimulus intensity. Such translational effects on intensity threshold were observed in both excitatory and fast-spiking inhibitory neurons, as well as in both monotonic and nonmonotonic (intensity-tuned) A1 neurons. Our results suggest that in a noise background, fundamental auditory representations are modulated through a background level-dependent linear shifting along intensity domain, which is equivalent to reducing stimulus intensity.
登录
查看更多内容
影响因子：
3.7
作者：
PHILLIPS, DP;KELLY, JB
通讯作者：
KELLY, JB
影响因子：
2.8
作者：
PHILLIPS, DP
通讯作者：
PHILLIPS, DP
影响因子：
16.2
作者：
Rabinowitz NC;Willmore BD;Schnupp JW;King AJ
通讯作者：
King AJ
影响因子：
1.8
作者：
Burkard, Robert F;Sims, Donald
通讯作者：
Sims, Donald
影响因子：
25
作者：
Li, Ling-yun;Li, Ya-tang;Zhou, Mu;Tao, Huizhong W.;Zhang, Li I.
通讯作者：
Zhang, Li I.