Intracortical multiplication of thalamocortical signals in mouse auditory cortex.

Intracortical multiplication of thalamocortical signals in mouse auditory cortex.
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DOI:
10.1038/nn.3493
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发表时间:
2013-09
影响因子:
25
通讯作者:
Zhang, Li I.
Zhang, Li I.
中科院分区:
医学1区
文献类型:
--
作者:
Li, Ling-yun;Li, Ya-tang;Zhou, Mu;Tao, Huizhong W.;Zhang, Li I.

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Cortical processing of sensory information initiates from the transformation of thalamically-relayed signals. By optogenetically silencing intracortical circuits to isolate thalamic inputs to layer 4 neurons, we show that intracortical excitation linearly amplifies thalamocortical responses underlying frequency and direction selectivity with preserved spectral range and tuning, and prolongs the response duration. This signal pre-amplification and prolongation enhances the salience of thalamocortically-relayed information and ensures its robust, faithful and more persistent representation.
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