Integrated Elastomeric Components for Autonomous Regulation of Sequential and Oscillatory Flow Switching in Microfluidic Devices.
Integrated Elastomeric Components for Autonomous Regulation of Sequential and Oscillatory Flow Switching in Microfluidic Devices.
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DOI：
10.1038/nphys1637
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发表时间：
2010-06-01
期刊：
影响因子：
19.6
通讯作者：
中科院分区：
文献类型：
--
作者：
提高微流控技术的可用性和能力的一个迫切需要是开发标准化、可扩展和多功能的控制系统。电子控制阀和泵通常用于动态流量调节，虽然有用，但也限制了方便性、可伸缩性和坚固性。这一缺点推动了设备嵌入式非电力流量控制系统的发展。然而，现有的在芯片上调节操作时序的方法仍然需要外部信号，例如流体流动、气泡、液塞或液滴的定时产生，或者化学成分或温度的改变。这里，我们描述了一种提供设备嵌入式流交换和时钟功能的策略。通过孔相互连接的物理间隙和空腔被制造成一个三层弹性体结构，以形成流体闸门网络，该网络可以自发地产生级联和振荡的流动输出，仅使用恒定的牛顿流体作为设备输入。由此得到的微流控衬底结构简单，可扩展，应该适用于各种材料。这种流动驱动的流体浇注方案将微电子电路的自主信号处理能力带到了微流体中，其中增加了具有不同化学或颗粒物种的当前信息的多样性，以及在当前发生化学反应和物理相互作用的操作中的丰富性。
A critical need for enhancing usability and capabilities of microfluidic technologies is the development of standardized, scalable, and versatile control systems. Electronically controlled valves and pumps typically used for dynamic flow regulation, although useful, can limit convenience, scalability, and robustness. This shortcoming has motivated development of device-embedded non-electrical flow-control systems. Existing approaches to regulate operation timing on-chip, however, still require external signals such as timed generation of fluid flow, bubbles, liquid plugs or droplets, or an alteration of chemical compositions or temperature. Here, we describe a strategy to provide device-embedded flow switching and clocking functions. Physical gaps and cavities interconnected by holes are fabricated into a three-layer elastomer structure to form networks of fluidic gates that can spontaneously generate cascading and oscillatory flow output using only a constant flow of Newtonian fluids as the device input. The resulting microfluidic substrate architecture is simple, scalable, and should be applicable to various materials. This flow-powered fluidic gating scheme brings the autonomous signal processing ability of microelectronic circuits to microfluidics where there is the added diversity in current information of having distinct chemical or particulate species and richness in current operation of having chemical reactions and physical interactions.
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影响因子：
6.1
作者：
Xie, J;Shih, J;Tai, YC
通讯作者：
Tai, YC
影响因子：
56.9
作者：
Unger, MA;Chou, HP;Quake, SR
通讯作者：
Quake, SR
DOI：
10.1073/pnas.0404353101
发表时间：
2004-11-09
影响因子：
11.1
作者：
Gu, W;Zhu, XY;Takayama, S
通讯作者：
Takayama, S
影响因子：
56.9
作者：
Groisman, A;Enzelberger, M;Quake, SR
通讯作者：
Quake, SR
影响因子：
56.9
作者：
Fuerstman, Michael J.;Garstecki, Piotr;Whitesides, George M.
通讯作者：
Whitesides, George M.