Genetic diversities of cytochrome B in Xinjiang Uyghur unveiled its origin and migration history.
Genetic diversities of cytochrome B in Xinjiang Uyghur unveiled its origin and migration history.
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新疆维吾尔族细胞色素B的遗传多样性揭示其起源和迁移历史
DOI：
10.1186/1471-2156-14-100
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发表时间：
2013-10-09
期刊：
影响因子：
2.9
通讯作者：
Zheng X
中科院分区：
文献类型：
--
作者：
Ablimit A;Qin W;Shan W;Wu W;Ling F;Ling KH;Zhao C;Zhang F;Ma Z;Zheng X
维吾尔族是欧亚大陆中部的众多人口之一，被认为与欧亚大陆东部和西部的人口有遗传关系。然而，关于欧亚大陆东部和西部遗传影响程度的相对重要性，存在一些不同的意见。此外，在不同的地理locations.ResultsIn这项研究中，我们是第一个报告的DNA多态性的细胞色素B在维吾尔族人群位于中国西北部的维吾尔族的遗传多样性。我们在240个样本中观察到了102个突变位点。样品中突变核苷酸的平均数为5.126。共观察到93种不同的单倍型。基因多样性为0.9480，区分力为0.9440。新疆维吾尔族人群中存在奠基者和瓶颈单倍型。新疆维吾尔族在遗传学上与中国人群的亲缘关系远大于与高加索人群的亲缘关系。此外，南、北方维吾尔族之间存在遗传多样性。新疆南部维吾尔族与中国人群之间的遗传距离有统计学意义，而新疆北方维吾尔族与中国人群之间的遗传距离无统计学意义。欧洲与东亚贡献的10个区域维吾尔族群体之间的群体和欧洲的贡献维吾尔增加从北到南geographic.ConclusionThis研究是第一次报告的DNA多态性的细胞色素B在维吾尔族人群。该研究也进一步证实了不同地理位置的维吾尔族之间存在着显著的遗传差异。
BackgroundUyghurs are one of the many populations of Central Eurasia that is considered to be genetically related to Eastern and Western Eurasian populations. However, there are some different opinions on the relative importance of the degree of Eastern and Western Eurasian genetic influence. In addition, the genetic diversity of the Uyghur in different geographic locations has not been clearly studied.ResultsIn this study, we are the first to report on the DNA polymorphism of cytochrome B in the Uyghur population located in Xinjiang in northwest China. We observed a total of 102 mutant sites in the 240 samples that were studied. The average number of mutated nucleotides in the samples was 5.126. A total of 93 different haplotypes were observed. The gene diversity and discrimination power were 0.9480 and 0.9440, respectively. There were founder and bottleneck haplotypes observed in Xinjiang Uyghurs. Xinjiang Uyghurs are more genetically related to Chinese population in genetics than to Caucasians. Moreover, there was genetic diversity between Uyghurs from the southern and northern regions. There was significance in genetic distance between the southern Xinjiang Uyghurs and Chinese population, but not between the northern Xinjiang Uyghurs and Chinese. The European vs. East Asian contribution to the ten regional Uyghur groups varies among the groups and the European contribution to the Uyghur increases from north to south geographically.ConclusionThis study is the first report on DNA polymorphisms of cytochrome B in the Uyghur population. The study also further confirms that there are significant genetic differences among the Uyghurs in different geographical locations.
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