Spatial neglect and attention networks.

Spatial neglect and attention networks.
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DOI:
10.1146/annurev-neuro-061010-113731
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发表时间:
2011
影响因子:
13.9
通讯作者:
Shulman GL
Shulman GL
中科院分区:
医学1区
文献类型:
--
作者:
Corbetta M;Shulman GL

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单侧空间忽略是一种常见的神经系统综合征后,主要是右半球损伤腹侧额顶叶皮层。我们建议,忽视反映赤字的编码显着性,控制空间注意力,并表示在一个以自我为中心的参考框架,结合非空间缺陷的重新定向,目标检测,唤醒/警惕。与将空间忽略与特定脑区结构损伤联系起来的理论相反,我们认为忽略更好地解释为分布式皮层网络的生理功能障碍。右顶叶、颞叶和额叶皮层的腹侧损伤导致忽视,直接损害了非空间功能,使右半球功能减退,导致任务诱发活动和控制空间注意力的背侧额顶叶网络的功能连接异常。忽视的解剖学和右半球优势来自与背侧注意网络相互作用的腹侧区域的解剖学和偏侧性。
Unilateral spatial neglect is a common neurological syndrome following predominantly right hemisphere injuries to ventral fronto-parietal cortex. We propose that neglect reflects deficits in the coding of saliency, control of spatial attention, and representation within an egocentric frame of reference, in conjunction with non-spatial deficits of reorienting, target detection, and arousal/vigilance. In contrast to theories that link spatial neglect to structural damage of specific brain regions, we argue that neglect is better explained by the physiological dysfunction of distributed cortical networks. The ventral lesions in right parietal, temporal, and frontal cortex that cause neglect directly impair non-spatial functions and hypoactivate the right hemisphere, inducing abnormalities in task-evoked activity and functional connectivity of a dorsal frontal-parietal network that controls spatial attention. The anatomy and right hemisphere dominance of neglect follows from the anatomy and laterality of the ventral regions that interact with the dorsal attention network.
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