Phase Entrainment of Brain Oscillations Causally Modulates Neural Responses to Intelligible Speech.
Phase Entrainment of Brain Oscillations Causally Modulates Neural Responses to Intelligible Speech.
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DOI：
10.1016/j.cub.2017.11.071
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发表时间：
2018-02-05
期刊：
影响因子：
--
通讯作者：
Davis MH
中科院分区：
文献类型：
--
作者：
Zoefel B;Archer-Boyd A;Davis MH
由于其周期性，神经振荡可能是处理节律性刺激输入的最佳“工具”。事实上，神经振荡与节律刺激的一致性（通常称为相位夹带）已被反复证明。相位夹带是当前语音处理理论的核心，并且与成功的语音理解相关。然而，降低语音清晰度的典型操作（例如，添加噪声和时间反转）可能会破坏夹带的关键声学线索（例如“声学边缘”）。因此，相位夹带和语音清晰度之间的关联可能只是“附带现象”；即，两者由于相同的操纵而下降，两者之间没有任何因果关系。在这里，我们使用经颅交流电刺激 (tACS) 来操纵神经振荡和言语节律之间的相位滞后，同时使用稀疏功能磁共振成像测量神经对可理解和不可理解的声码刺激的反应。我们发现这种操作显着调节了颞上回对可理解语音的 BOLD 反应，并且 BOLD 调节的强度与行为任务中表现的阶段性调节相关。重要的是，这些发现在难以理解的言语和假刺激期间不存在。因此，我们证明相位夹带对可理解语音的神经反应具有特定的因果影响。我们的研究结果不仅为理解人类语音理解能力的神经基础迈出了重要一步，而且还提出了未来可以探索的增强语音感知的新方法。使用 tACS 操纵神经振荡和言语节律之间的相位滞后。这种操纵调节了颞上回对言语的 BOLD 反应。在可理解的而非不可理解的言语中观察到了 tACS 效应。结果显示了言语处理过程中神经夹带的因果作用。Zoefel 等人使用同步 tACS-fMRI 记录。研究表明，神经振荡与刺激节律的一致性会因果性地调节神经对言语的反应。该效果特定于可理解的语音，支持神经夹带是一种专为优化语音处理而定制的机制的概念。
Due to their periodic nature, neural oscillations might represent an optimal “tool” for the processing of rhythmic stimulus input. Indeed, the alignment of neural oscillations to a rhythmic stimulus, often termed phase entrainment, has been repeatedly demonstrated. Phase entrainment is central to current theories of speech processing and has been associated with successful speech comprehension. However, typical manipulations that reduce speech intelligibility (e.g., addition of noise and time reversal) could destroy critical acoustic cues for entrainment (such as “acoustic edges”). Hence, the association between phase entrainment and speech intelligibility might only be “epiphenomenal”; i.e., both decline due to the same manipulation, without any causal link between the two. Here, we use transcranial alternating current stimulation (tACS) to manipulate the phase lag between neural oscillations and speech rhythm while measuring neural responses to intelligible and unintelligible vocoded stimuli with sparse fMRI. We found that this manipulation significantly modulates the BOLD response to intelligible speech in the superior temporal gyrus, and the strength of BOLD modulation is correlated with a phasic modulation of performance in a behavioral task. Importantly, these findings are absent for unintelligible speech and during sham stimulation; we thus demonstrate that phase entrainment has a specific, causal influence on neural responses to intelligible speech. Our results not only provide an important step toward understanding the neural foundation of human abilities at speech comprehension but also suggest new methods for enhancing speech perception that can be explored in the future. Phase lag between neural oscillations and speech rhythm was manipulated using tACS This manipulation modulated the BOLD response to speech in superior temporal gyrus tACS effects were observed for intelligible, but not unintelligible, speech Results show a causal role of neural entrainment during speech processing Using simultaneous tACS-fMRI recordings, Zoefel et al. show that the alignment of neural oscillations to stimulus rhythm causally modulates neural responses to speech. The effect is specific for intelligible speech, supporting the notion that neural entrainment is a mechanism tailored to optimize speech processing.
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影响因子：
3.5
作者：
Cusack R;Vicente-Grabovetsky A;Mitchell DJ;Wild CJ;Auer T;Linke AC;Peelle JE
通讯作者：
Peelle JE
影响因子：
25
作者：
通讯作者：
--
DOI：
10.1523/jneurosci.5297-12.2013
发表时间：
2013-03-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ding N;Simon JZ
通讯作者：
Simon JZ
影响因子：
9.8
作者：
Gross J;Hoogenboom N;Thut G;Schyns P;Panzeri S;Belin P;Garrod S
通讯作者：
Garrod S
影响因子：
2.9
作者：
de Berker AO;Bikson M;Bestmann S
通讯作者：
Bestmann S