Predicting the behavioral impact of transcranial direct current stimulation: issues and limitations.
Predicting the behavioral impact of transcranial direct current stimulation: issues and limitations.
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DOI：
10.3389/fnhum.2013.00613
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发表时间：
2013
影响因子：
2.9
通讯作者：
Bestmann S
中科院分区：
文献类型：
--
作者：
de Berker AO;Bikson M;Bestmann S
弱电流在人脑的经颅应用已经广泛使用了十年，为非侵入性改变人脑功能提供了一种简单而强大的工具。然而，我们对电流传递及其对神经回路的影响的理解仍有许多不足之处。我们认为，经颅直流电刺激(Tdcs)得出的结论的可信度取决于对tdcs如何工作的现实解释，而我们目前对tdcs的理解限制了该技术在人脑功能定位方面的使用。我们概述了需要取得进展的两个中心问题：电流的本地化及其功能后果的预测。我们鼓励实验者避免对经颅电流刺激机制的简单化解释。我们建议使用个体化的电流模型，结合计算神经刺激来提供解释tdcs的生理影响的机制框架。我们希望通过对电流流动和作用的更丰富的机械描述，能够深入了解经颅电流影响行为的生物过程，从而导致更有效的刺激方案，并使tdcs得出更有力的结论。
The transcranial application of weak currents to the human brain has enjoyed a decade of widespread use, providing a simple and powerful tool for non-invasively altering human brain function. However, our understanding of current delivery and its impact upon neural circuitry leaves much to be desired. We argue that the credibility of conclusions drawn with transcranial direct current stimulation (tDCS) is contingent upon realistic explanations of how tDCS works, and that our present understanding of tDCS limits the technique’s use to localize function in the human brain. We outline two central issues where progress is required: the localization of currents, and predicting their functional consequence. We encourage experimenters to eschew simplistic explanations of mechanisms of transcranial current stimulation. We suggest the use of individualized current modeling, together with computational neurostimulation to inform mechanistic frameworks in which to interpret the physiological impact of tDCS. We hope that through mechanistically richer descriptions of current flow and action, insight into the biological processes by which transcranial currents influence behavior can be gained, leading to more effective stimulation protocols and empowering conclusions drawn with tDCS.
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影响因子：
5.7
作者：
Edwards, Dylan;Cortes, Mar;Datta, Abhishek;Minhas, Preet;Wassermann, Eric M.;Bikson, Marom
通讯作者：
Bikson, Marom
DOI：
10.1523/jneurosci.4927-12.2013
发表时间：
2013-03-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Iuculano T;Cohen Kadosh R
通讯作者：
Cohen Kadosh R
影响因子：
7.7
作者：
Brunoni, Andre Russowsky;Nitsche, Michael A.;Bolognini, Nadia;Bikson, Marom;Wagner, Tim;Merabet, Lotfi;Edwards, Dylan J.;Valero-Cabre, Antoni;Rotenberg, Alexander;Pascual-Leone, Alvaro;Ferrucci, Roberta;Priori, Alberto;Boggio, Paulo Sergio;Fregni, Felipe
通讯作者：
Fregni, Felipe
DOI：
10.1111/nyas.12110
发表时间：
2013-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE
影响因子：
--
作者：
Bestmann, Sven;Feredoes, Eva
通讯作者：
Feredoes, Eva
DOI：
10.1109/embc.2012.6347465
发表时间：
2012
期刊：
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子：
--
作者：
Dmochowski JP;Bikson M;Datta A;Richardson J;Fridriksson J;Parra LC
通讯作者：
Parra LC