From hydra regeneration to human brain structural plasticity: a long trip through narrowing roads.
From hydra regeneration to human brain structural plasticity: a long trip through narrowing roads.
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DOI：
10.1100/tsw.2011.113
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发表时间：
2011-06-09
影响因子：
--
通讯作者：
Bonfanti L
中科院分区：
文献类型：
--
作者：
Bonfanti L
再生是一种在一生中保持形式和功能的策略。在过去的几十年里，在整个系统发育树上进行的动物模型研究蓬勃发展，以寻找再生过程的潜在机制。这类研究的发展与干细胞研究严格相关，两者都被视为再生医学最有希望的结果之一；然而，再生、干细胞和组织修复似乎并不遵循不同动物物种和组织的逻辑路径。结果，一些哺乳动物的器官，如肾脏和大脑，失去了大部分的再生能力。人类神经系统虽然拥有神经干细胞，但却处于“多年生”组织的极端位置。此外，它还受到神经退行性疾病的影响，这些疾病的沉重负担因寿命延长而加重。这篇综述从比较背景下组织再生的基本原理出发，试图回答这样一个问题：在一个配备了许多解剖/进化限制的哺乳动物大脑中，再生医学能在多大程度上得到解决？
Regeneration is a strategy to maintain form and function throughout life. Studies carried out on animal models throughout the phylogenetic tree have flourished in the last decades in search of mechanisms underlying the regenerative processes. The development of such studies is strictly linked with stem cell research and both are viewed as one of the most promising outcomes for regenerative medicine; yet, regeneration, stem cells, and tissue repair do not seem to follow a logical path through the different animal species and tissues. As a result, some mammalian organs, e.g., kidney and brain, have lost most of their regenerative capacity. The human nervous system, although harboring neural stem cells, is placed at the extreme of “perennial” tissues. In addition, it is affected by neurodegenerative diseases, whose heavy burden is heightened by enhanced life spans. This review, starting from the basic principles of tissue regeneration viewed in a comparative context, tries to answer this question: To which extent can regenerative medicine be figured out in a mammalian brain equipped with many anatomical/evolutionary constraints?
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影响因子：
5.3
作者：
ATTARDI, DG;SPERRY, RW
通讯作者：
SPERRY, RW
影响因子：
2.5
作者：
Azevedo, Frederico A. C.;Carvalho, Ludmila R. B.;Herculano-Houzel, Suzana
通讯作者：
Herculano-Houzel, Suzana
影响因子：
9.2
作者：
Benfey, PN
通讯作者：
Benfey, PN
DOI：
10.1016/j.bbrc.2010.04.037
发表时间：
2010-05-21
影响因子：
3.1
作者：
Arenas, Ernest
通讯作者：
Arenas, Ernest
影响因子：
1.5
作者：
BADER, D;OBERPRILLER, JO
通讯作者：
OBERPRILLER, JO