Effects of cardiac timing and peripheral resistance on measurement of pulse wave velocity for assessment of arterial stiffness.
Effects of cardiac timing and peripheral resistance on measurement of pulse wave velocity for assessment of arterial stiffness.
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心脏计时和外周阻力对测量脉搏波速度以评估动脉僵硬度的影响
DOI：
10.1038/s41598-017-05807-x
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发表时间：
2017-07-20
影响因子：
4.6
通讯作者：
Avolio A
中科院分区：
文献类型：
--
作者：
Xiao H;Butlin M;Tan I;Avolio A
为了研究心率（HR）、左心室射血时间（LVET）和波反射对脉搏波传导速度（PWV）评估的动脉硬度的影响，开发了基于动脉树传输线模型的脉搏波传播仿真系统（PWPSim），并将其应用于脉搏波传播的研究。HR、LVET、动脉弹性模量和外周阻力分别增加60 ~ 100次/min、0.1 ~ 0.45秒、0.5 ~ 1.5倍和0.5 ~ 1.5倍。通过交叉切线法（cfPWVtan和baPWVtan）、最大斜率（cfPWVmax和baPWVmax）和使用Moens-Korteweg方程（和）计算颈动脉-股动脉PWV（cfPWV）和肱踝PWV（baPWV）。结果表明，cfPWV和baPWV与动脉弹性模量显着增加，但不增加与心率时，使用一个恒定的弹性模量。然而，cfPWVtan和baPWVtan具有显著的LVET依赖性（每50 ms为0.17 ± 0.13和0.17 ± 0.08 m/s），cfPWVtan、cfPWVmax、baPWVtan和baPWVmax具有低外周阻力依赖性（每10%外周阻力分别为0.04 ± 0.01、0.06 ± 0.04、0.06 ± 0.03和0.09 ± 0.07 m/s）。这项研究表明，当动脉弹性模量恒定时，与HR和外周阻力相比，LVET对计算的PWV的影响占主导地位。
To investigate the effects of heart rate (HR), left ventricular ejection time (LVET) and wave reflection on arterial stiffness as assessed by pulse wave velocity (PWV), a pulse wave propagation simulation system (PWPSim) based on the transmission line model of the arterial tree was developed and was applied to investigate pulse wave propagation. HR, LVET, arterial elastic modulus and peripheral resistance were increased from 60 to 100 beats per minute (bpm), 0.1 to 0.45 seconds, 0.5 to 1.5 times and 0.5 to 1.5 times of the normal value, respectively. Carotid-femoral PWV (cfPWV) and brachial-ankle PWV (baPWV) were calculated by intersecting tangent method (cfPWVtanand baPWVtan), maximum slope (cfPWVmaxand baPWVmax), and using the Moens-Korteweg equation (and). Results showed cfPWV and baPWV increased significantly with arterial elastic modulus but did not increase with HR when using a constant elastic modulus. However there were significant LVET dependencies of cfPWVtanand baPWVtan(0.17 ± 0.13 and 0.17 ± 0.08 m/s per 50 ms), and low peripheral resistance dependencies of cfPWVtan, cfPWVmax, baPWVtanand baPWVmax(0.04 ± 0.01, 0.06 ± 0.04, 0.06 ± 0.03 and 0.09 ± 0.07 m/s per 10% peripheral resistance), respectively. This study demonstrated that LVET dominates the effect on calculated PWV compared to HR and peripheral resistance when arterial elastic modulus is constant.
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