The eyes have it: hippocampal activity predicts expression of memory in eye movements.

The eyes have it: hippocampal activity predicts expression of memory in eye movements.
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DOI:
10.1016/j.neuron.2009.08.025
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发表时间:
2009-09-10
期刊:
影响因子:
16.2
通讯作者:
Ranganath, Charan
Ranganath, Charan
中科院分区:
医学1区
文献类型:
--
作者:
Hannula, Deborah E.;Ranganath, Charan

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尽管人们普遍认为海马体对外显情景记忆检索至关重要,但当外显检索失败时,该区域是否也能支持关系记忆的间接表达仍存在争议。在这里,我们使用功能性磁共振成像(fMRI)和同时进行的间接的、基于眼球运动的记忆测量,我们获得了海马活动预测在随后的观看模式中的关系记忆表达的证据,即使在显式的、有意识的检索失败时也是如此。此外,在正确试验中,外侧前额叶皮层的活动以及海马体和前额叶皮层之间的功能连接比错误试验中更大。总之,这些结果表明,即使外显检索失败,海马体活动也可以支持关系记忆的表达,并且可能需要招募更广泛的皮层网络来支持外显联想识别。
Although there is widespread agreement that the hippocampus is critical for explicit episodic memory retrieval, it is controversial whether this region can also support indirect expressions of relational memory when explicit retrieval fails. Here, using functional magnetic resonance imaging (fMRI) with concurrent indirect, eye-movement-based memory measures, we obtained evidence that hippocampal activity predicted expressions of relational memory in subsequent patterns of viewing, even when explicit, conscious retrieval failed. Additionally, activity in the lateral prefrontal cortex, and functional connectivity between the hippocampus and prefrontal cortex was greater for correct than for incorrect trials. Together, these results suggest that hippocampal activity can support the expression of relational memory even when explicit retrieval fails, and that recruitment of a broader cortical network may be required to support explicit associative recognition.
DOI: 10.1002/hipo.1093
发表时间: 2001-01-01
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