Prevalence of serum neutralizing antibodies to adenovirus type 5 (Ad5) and 41 (Ad41) in children is associated with age and sanitary conditions.
Prevalence of serum neutralizing antibodies to adenovirus type 5 (Ad5) and 41 (Ad41) in children is associated with age and sanitary conditions.
复制标题
儿童中 5 型腺病毒 (Ad5) 和 41 型 (Ad41) 血清中和抗体的患病率与年龄和卫生条件有关
DOI：
10.1016/j.vaccine.2016.09.043
复制
发表时间：
2016-11-04
期刊：
影响因子：
5.5
通讯作者：
Lu ZZ
中科院分区：
文献类型：
--
作者：
Yang WX;Zou XH;Jiang SY;Lu NN;Han M;Zhao JH;Guo XJ;Zhao SC;Lu ZZ
对成人和儿童的 Ad5 和 Ad41 血清中和抗体进行了滴定。儿童中 NAB 的患病率与年龄和卫生条件有关。 Ad5 和 Ad41 之间的 NAb 效价分布模式非常不同。 Ad41 载体候选疫苗可能有着光明的前景。中和抗体（NAb）可以抑制腺病毒（Ad）载体疫苗的免疫原性。基于人类 41 型腺病毒 (Ad41) 的载体系统已被构建并用于开发重组疫苗。在这里，我们试图研究中国青海省儿童和成人中 Ad5 和 Ad41 NAb 的血清流行率。西宁市成年人Ad5和Ad41 NAb阳性率（效价⩾40）分别为75.7%和94.7%。两种病毒在成人中的 Nab 中/高阳性率（效价⩾160）非常接近（Ad5 为 70.4%，Ad41 为 73.5%）。在儿童中观察到这两种病毒的 NAb 血清流行率随年龄而增加。西宁市城西区儿童3.3~4.6岁时，Ad41的NAb阳性率达到50%，比Ad5早约1.5年。有趣的是，NAb 水平也与幼儿的卫生条件有关。对于 Ad5，来自卫生条件相对较好的城市或城镇的儿童（0.2-3.0 岁）有 8-15% 的 NAB 呈中/高阳性，而来自乡村的儿童的这一比例为 62%。对于 Ad41，22% 来自城市的儿童、47% 来自城镇的儿童和 88% 来自乡村的儿童拥有中/高阳性 NAB。详细讨论了NAb滴度分布对Ad41载体疫苗应用可能产生的影响。我们的结果表明，来自卫生条件差地区的儿童应被纳入全面的 Ad Nab 血清阳性率研究，并为 Ad41 载体的应用提供了见解。
Serum neutralizing antibodies to Ad5 and Ad41 in adults and children were titrated. Prevalence of NAb in children was associated with age and sanitary conditions. NAb titer distribution pattern was very different between Ad5 an Ad41. Ad41 vectored vaccine candidates might have a bright future. Neutralizing antibody (NAb) can dampen the immunogenicity of adenovirus (Ad) vector-based vaccine. Vector systems based on human adenovirus type 41 (Ad41) have been constructed and used to develop recombinant vaccines. Here, we attempted to study the seroprevalence of NAbs to Ad5 and Ad41 among children and adults in Qinghai province, China. The positive rates (titer ⩾ 40) of Ad5 and Ad41 NAb in adults from Xining city were 75.7% and 94.7%, respectively. The moderate/high-positive rates (titer ⩾ 160) of NAb were quite close between the two viruses in adults (70.4% for Ad5 and 73.5% for Ad41). Age-dependent increase of NAb seroprevalence was observed for both viruses in children. NAb-positive rate of Ad41 reached 50% at 3.3–4.6 years of age for children from Chengxi district, Xining city, approximately 1.5 years earlier than that of Ad5 did. Interestingly, NAb level was also associated with sanitary conditions among young children. For Ad5, 8–15% children (0.2–3.0 years of age) from city or town, where the sanitations were relatively better, had moderate/high-positive NAb, while the same rate was 62% for children from villages. For Ad41, 22% children from city, 47% from town and 88% from villages possessed moderate/high-positive NAb. The possible influence of NAb titer distributions on the application of Ad41-vectored vaccines was discussed in detail. Our results suggested that children from places with poor sanitations should be included for comprehensive Ad NAb seroprevalence studies, and provided insights to the applications of Ad41 vectors.
登录
查看更多内容
DOI：
10.1111/j.1348-0421.1970.tb00538.x
发表时间：
1970-01-01
期刊：
JAPANESE JOURNAL OF MICROBIOLOGY
影响因子：
--
作者：
HASHIMTO, K;SUGIYAMA, T;SASAKI, S
通讯作者：
SASAKI, S
影响因子：
168.9
作者：
Buchbinder, Susan P.;Mehrotra, Devon V.;Duerr, Ann;Fitzgerald, Daniel W.;Mogg, Robin;Li, David;Gilbert, Peter B.;Lama, Javier R.;Marmor, Michael;del Rio, Carlos;McElrath, M. Juliana;Casimiro, Danilo R.;Gottesdiener, Keith M.;Chodakewitz, Jeffrey A.;Corey, Lawrence;Robertson, Michael N.
通讯作者：
Robertson, Michael N.
影响因子：
12.7
作者：
KIDD, AH;BANATVALA, JE;DEJONG, JC
通讯作者：
DEJONG, JC
影响因子：
6.4
作者：
Guo X;Deng Y;Chen H;Lan J;Wang W;Zou X;Hung T;Lu Z;Tan W
通讯作者：
Tan W
影响因子：
3.6
作者：
Khare R;Chen CY;Weaver EA;Barry MA
通讯作者：
Barry MA