Scaffolds to control inflammation and facilitate dental pulp regeneration.
Scaffolds to control inflammation and facilitate dental pulp regeneration.
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DOI：
10.1016/j.joen.2014.01.019
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发表时间：
2014-04
影响因子：
4.2
通讯作者：
D'Souza RN
中科院分区：
文献类型：
--
作者：
Colombo JS;Moore AN;Hartgerink JD;D'Souza RN
在牙科中，维持重要的牙髓是至关重要的，因为通过根管治疗失活的牙齿可能会变得更脆，并且随着时间的推移容易发生结构性失效。晚期龋损可通过在整个组织中传播持续的炎症反应而不可逆地损害牙髓。虽然炎症反应最初驱动组织修复，但持续的炎症对活髓具有巨大的破坏性影响，最终导致组织完全坏死并需要将其去除。牙齿失活的影响已经引起了人们对开发生物活性材料的极大兴趣，该生物活性材料通过利用牙髓的自我修复能力来促进受损牙髓组织的再生。在考虑牙髓炎驱动组织破坏的过程中，很明显，支持牙髓组织再生的重要步骤是减轻炎症。巨噬细胞是免疫反应的关键介质，由于它们能够转变为促消退表型，因此可能在牙髓炎消退中发挥关键作用。这一过程可以由消退素驱动，消退素是一种衍生自脂肪酸的分子家族，作为治疗剂显示出巨大的前景。在这篇综述中，我们概述了通过炎症的快速衰减来保持牙髓自我修复能力的重要性。潜在的治疗方式，如转移巨噬细胞的亲解决表型与resolvins的描述，并提出了一系列已知的材料，以支持牙髓的再生。
In dentistry, the maintenance of a vital dental pulp is of paramount importance, as teeth devitalized by root canal treatment may become more brittle and prone to structural failure over time. Advanced carious lesions can irreversibly damage the dental pulp by propagating a sustained inflammatory response throughout the tissue. While the inflammatory response initially drives tissue repair, sustained inflammation has an enormously destructive effect on the vital pulp, eventually leading to total necrosis of the tissue and necessitating its removal. The implications of tooth devitalization have driven significant interest in the development of bioactive materials that facilitate the regeneration of damaged pulp tissues by harnessing the capacity of the dental pulp for self-repair. In considering the process by which pulpitis drives tissue destruction, it is clear that an important step in supporting the regeneration of pulpal tissues is the attenuation of inflammation. Macrophages, key mediators of the immune response, may play a critical role in the resolution of pulpitis due to their ability to switch to a pro-resolution phenotype. This process can be driven by the resolvins, a family of molecules derived from fatty acids that show great promise as therapeutic agents. In this review, we outline the importance of preserving the capacity of the dental pulp to self-repair through the rapid attenuation of inflammation. Potential treatment modalities, such as shifting macrophages to a pro-resolving phenotype with resolvins are described, and a range of materials known to support the regeneration of dental pulp are presented.
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影响因子：
6.2
作者：
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通讯作者：
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