Statins may aggravate myasthenia gravis.
Statins may aggravate myasthenia gravis.
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DOI：
10.1002/mus.21074
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发表时间：
2008-09
期刊：
影响因子：
3.4
通讯作者：
Claussen, Gwendolyn C.
中科院分区：
文献类型：
--
作者：
Oh, Shin J.;Dhall, Rohit;Young, Angela;Morgan, Marla B.;Lu, Liang;Claussen, Gwendolyn C.
他汀类药物引起的肌病是众所周知的，但降胆固醇药物对重症肌无力（MG）的影响还没有详细的研究。我们调查了他汀类药物的使用及其对此病患者MG的影响。系统地从伯明翰阿拉巴马大学神经肌肉疾病诊所接受治疗的170名患者中获得了他汀类药物的信息。当他汀类药物治疗后4个月内出现新的肌痛综合征或MG恶化时，没有发现其他可能的原因，并且无论是否停用他汀类药物均出现临床改善，我们认为这些症状是他汀类药物引起的。54名患者（31%）服用他汀类药物。与非他汀类药物组相比，他汀类药物组的男性和老年患者比例更高。7例（13%）患者出现肌痛综合征，但在停用他汀类药物后无任何后遗症。6例（11%）患者发生MG恶化，与MG类型或他汀类药物品牌无关。MG恶化与肌痛综合征无关，在他汀类药物治疗1-16周内主要涉及眼球症状。在4例患者中，需要额外的治疗来逆转MG恶化。他汀类药物对大多数MG患者是安全的，但在使用他汀类药物时必须密切观察是否有MG恶化的可能。
Statin-induced myopathy is well-known, but the effect of cholesterol-lowering agents on myasthenia gravis (MG) has not been studied in detail. We investigated statin use and its effects on MG among patients with this disease. Statin information was systemically obtained from 170 patients being treated at the Neuromuscular Disease Clinic at the University of Alabama at Birmingham. When a new myalgic syndrome or worsening of MG developed within 4 months after statin treatment, no other likely cause was found, and clinical improvement occurred either with or without discontinuation of the statin, we considered these symptoms to be statin-induced. Fifty-four patients (31%) were on statins. The statin group had proportionally more males, and older patients compared with the non-statin group. A myalgic syndrome was noted in 7 (13%) patients, but it resolved without any sequelae after withdrawal of the statin. MG worsening occurred in 6 (11%) patients without regard to type of MG or brand of statin. MG worsening occurred independently of myalgic syndrome and involved predominantly oculobulbar symptoms within 1-16 weeks of statin treatment. In 4 patients, additional treatment was needed to reverse MG worsening. Statins are safe in the majority of MG patients, but their use must be accompanied by close observation for possible MG worsening.
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影响因子：
3.4
作者：
Baker, Steven K.;Tarnopolsky, Mark A.
通讯作者：
Tarnopolsky, Mark A.
影响因子：
1.6
作者：
Purvin, V;Kawasaki, A;Kesler, A
通讯作者：
Kesler, A
影响因子：
3.4
作者：
SONODA, Y;GOTOW, T;OSAME, M
通讯作者：
OSAME, M
影响因子：
--
作者：
Tsivgoulis, Georgios;Spengos, Konstantinos;Manta, Panagiota
通讯作者：
Manta, Panagiota
影响因子：
37.8
作者：
Pasternak, RC;Smith, SC;Lenfant, C
通讯作者：
Lenfant, C