Effects of MCI-154, a calcium sensitizer, on left ventricular systolic and diastolic function in pacing-induced heart failure in the dog.
Effects of MCI-154, a calcium sensitizer, on left ventricular systolic and diastolic function in pacing-induced heart failure in the dog.
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MCI-154（一种钙敏化剂）对起搏引起的狗心力衰竭中左心室收缩和舒张功能的影响。
DOI：
10.1161/01.cir.95.3.732
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发表时间：
1997
期刊：
影响因子：
37.8
通讯作者：
Takeshi Nakano
中科院分区：
文献类型：
--
作者：
S. Teramura;T. Yamakado;M. Maeda;Takeshi Nakano
背景
MCI-154是一种正性肌力增强剂，可增加肌丝对钙离子的反应。目前尚不清楚MCI-154是否对慢性心力衰竭患者的左心功能不全有有益影响。我们观察了MCI-154对起搏性心力衰竭犬左室收缩和舒张期功能的影响。
方法和结果
我们研究了8只麻醉犬在快速右室起搏前和起搏后2~4周。在对照组和心力衰竭状态下，分别在静脉注射MCI-154(I.O.微克·kg~(-1)·min~(-1)，15分钟)前和静脉注射MCI-154期间进行左心室造影，同时测量左室压(尖端压力计)。左心室容量动力学由左心室血管造影的逐帧(20ms)分析得出。在心力衰竭患者中，MCI-154(+1.94毫米汞/毫升，P<；0.05)改善的程度与对照状态(+2.47毫米汞/毫升，P<；0.05)相似。MCI-154还加速了两种状态下的左心室松弛，通过等容压力衰减时间常数(t1/2)进行评估。心力衰竭患者MCI-154的T1/2绝对值下降显著大于对照组(-8.2ms比-3.1ms，P<；0.05)。在心力衰竭时，MCI-154使左室舒张压-容量关系明显下移，提示舒张期扩张性增加。
结论
在慢性心力衰竭模型中，MCI-154不仅改善了左心室收缩功能，而且还改善了舒张性和扩张性。
BACKGROUND
MCI-154 is a positive inotropic agent that increases the myofilament response to Ca2+. Whether MCI-154 has beneficial effects on left ventricular dysfunction in chronic heart failure is not known. We examined the effects of MCI-154 on left ventricular systolic and diastolic function in pacing-induced heart failure in dogs.
METHODS AND RESULTS
We studied eight anesthetized dogs before and 2 to 4 weeks after rapid right ventricular pacing. Left cineventriculograms with simultaneous left ventricular pressures (tip manometer) were obtained before and during intravenous administration of MCI-154 (I.O. microgram.kg-1.min-1 for 15 minutes) in the control and heart-failure states. Left ventricular volume dynamics was derived from frame-by-frame (20-ms) analyses of left ventricular angiograms. In heart failure, left ventricular contractility as assessed by shifts of the end-systolic pressure-volume ratio, evaluated by inferior vena cava occlusion, was improved by MCI-154 (+ 1.94 mm Hg/mL, P < .05) to an extent similar to that in the control state (+2.47 mm Hg/mL, P < .05). MCI-154 also accelerated left ventricular relaxation, assessed by the time constant of isovolumic pressure decay (T1/2), in both states. The absolute decrease in T1/2 with MCI-154 in heart failure was significantly greater than in the control state (-8.2 versus -3.1 ms, P < .05). In heart failure, MCI-154 shifted the left ventricular diastolic pressure-volume relation clearly downward, suggesting increased diastolic distensibility.
CONCLUSIONS
MCI-154 improved not only left ventricular systolic function but also diastolic relaxation and distensibility in a chronic heart failure model.
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DOI：
10.1056/nejm199108293250906
发表时间：
1991
期刊：
The New England journal of medicine
影响因子：
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