The Need to Shift from Morphological to Structural Assessment for Carotid Plaque Vulnerability.
The Need to Shift from Morphological to Structural Assessment for Carotid Plaque Vulnerability.
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DOI：
10.3390/biomedicines10123038
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发表时间：
2022-11-24
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
管腔狭窄程度通常被认为是判断动脉粥样硬化风险的重要指标。但狭窄程度相同或相似的患者，斑块形态和生物力学因素可能存在显著差异。本研究调查了三名颈动脉粥样硬化患者，狭窄范围相似。利用我们开发的流体-结构相互作用（FSI）建模方法，本研究分析和比较的形态和生物力学参数的三个病人。虽然他们的颈动脉狭窄程度相似，但斑块成分显示出显着差异。患者2的时均壁面切应力（TAWSS）分布范围较患者1和患者3更宽。与其他两名患者相比，患者2的斑块应力也小得多。3例患者的TAWSS和斑块应力差异有统计学意义。这项研究表明，斑块的脆弱性不是由一个单一的形态因素，而是由组合结构。有必要将斑块破裂风险的形态学评估转化为结构评估。
Degree of luminal stenosis is generally considered to be an important indicator for judging the risk of atherosclerosis burden. However, patients with the same or similar degree of stenosis may have significant differences in plaque morphology and biomechanical factors. This study investigated three patients with carotid atherosclerosis within a similar range of stenosis. Using our developed fluid–structure interaction (FSI) modelling method, this study analyzed and compared the morphological and biomechanical parameters of the three patients. Although their degrees of carotid stenosis were similar, the plaque components showed a significant difference. The distribution range of time-averaged wall shear stress (TAWSS) of patient 2 was wider than that of patient 1 and patient 3. Patient 2 also had a much smaller plaque stress compared to the other two patients. There were significant differences in TAWSS and plaque stresses among three patients. This study suggests that plaque vulnerability is not determined by a single morphological factor, but rather by the combined structure. It is necessary to transform the morphological assessment into a structural assessment of the risk of plaque rupture.
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影响因子：
10.6
作者：
Chan, TF;Vese, LA
通讯作者：
Vese, LA
DOI：
10.1007/978-3-319-59548-1_10
发表时间：
2018-01-01
期刊：
BIOMEDICAL TECHNOLOGY: MODELING, EXPERIMENTS AND SIMULATION
影响因子：
--
作者：
Guerciotti, Bruno;Vergara, Christian
通讯作者：
Vergara, Christian
基于 MRI 的患者特异性人颈动脉粥样硬化血管材料特性变化、血管位置和长期随访
影响因子：
3.7
作者：
Wang Q;Canton G;Guo J;Guo X;Hatsukami TS;Billiar KL;Yuan C;Wu Z;Tang D
通讯作者：
Tang D
影响因子：
4.6
作者：
Gijsen, Frank J. H.;Vis, Bas;Akyildiz, Ali C.
通讯作者：
Akyildiz, Ali C.
DOI：
10.1115/1.2795948
发表时间：
1996-02-01
影响因子：
1.7
作者：
He, XJ;Ku, DN
通讯作者：
Ku, DN