Structure-based neutralizing mechanisms for SARS-CoV-2 antibodies.
Structure-based neutralizing mechanisms for SARS-CoV-2 antibodies.
复制标题
SARS-CoV-2 抗体基于结构的中和机制
DOI：
10.1080/22221751.2022.2125348
复制
发表时间：
2022-12
影响因子：
13.2
通讯作者：
中科院分区：
文献类型：
--
作者：
COVID-19大流行造成的毁灭性经济和公共卫生后果促使科学界和制药公司努力开发针对SARS-CoV-2的抗体疗法。这些努力是令人鼓舞和富有成效的。在过去的两年中，已经开发了前所未有的大量单克隆抗体（mAb），其靶向刺突蛋白上的大范围表位。结构生物学的发展，特别是冷冻电镜技术的发展，为这些单克隆抗体的分子中和机制提供了结构上的见解。此外，中和抗体在保护宿主免受感染方面至关重要。因此，了解抗体中和机制对于优化有效的基于抗体的治疗方法和开发下一代泛冠状病毒疫苗至关重要。本文从分子水平和结构水平综述了抗SARS-CoV-2抗体中和机制的最新研究进展。
The devastating economic and public health consequences caused by the COVID-19 pandemic have prompted outstanding efforts from the scientific community and pharmaceutical companies to develop antibody-based therapeutics against SARS-CoV-2. Those efforts are encouraging and fruitful. An unprecedentedly large number of monoclonal antibodies (mAbs) targeting a large spectrum of epitopes on the spike protein has been developed in the last two years. The development of structural biology, especially the cryo-EM technology, provides structural insights into the molecular neutralizing mechanisms of those mAbs. Moreover, neutralizing antibodies are essential in protecting host from infection. Therefore, understanding the antibody neutralizing mechanism is critical for optimizing effective antibody-based therapeutics and developing next-generation pan-coronavirus vaccines. This review summarizes the latest understanding of antibody neutralizing mechanisms against SARS-CoV-2 at the molecular and structural levels.
登录
查看更多内容
SARS-COV-2中和抗体的结构洞察力和合成的调节。
影响因子：
64.5
作者：
Asarnow D;Wang B;Lee WH;Hu Y;Huang CW;Faust B;Ng PML;Ngoh EZX;Bohn M;Bulkley D;Pizzorno A;Ary B;Tan HC;Lee CY;Minhat RA;Terrier O;Soh MK;Teo FJ;Yeap YYC;Seah SGK;Chan CEZ;Connelly E;Young NJ;Maurer-Stroh S;Renia L;Hanson BJ;Rosa-Calatrava M;Manglik A;Cheng Y;Craik CS;Wang CI
通讯作者：
Wang CI
影响因子：
64.8
作者：
Barnes CO;Jette CA;Abernathy ME;Dam KA;Esswein SR;Gristick HB;Malyutin AG;Sharaf NG;Huey-Tubman KE;Lee YE;Robbiani DF;Nussenzweig MC;West AP Jr;Bjorkman PJ
通讯作者：
Bjorkman PJ
影响因子：
30.5
作者：
He, Wan-ting;Musharrafieh, Rami;Song, Ge;Dueker, Katharina;Tse, Longping V.;Martinez, David R.;Schafer, Alexandra;Callaghan, Sean;Yong, Peter;Beutler, Nathan;Torres, Jonathan L.;Volk, Reid M.;Zhou, Panpan;Yuan, Meng;Liu, Hejun;Anzanello, Fabio;Capozzola, Tazio;Parren, Mara;Garcia, Elijah;Rawlings, Stephen A.;Smith, Davey M.;Wilson, Ian A.;Safonova, Yana;Ward, Andrew B.;Rogers, Thomas F.;Baric, Ralph S.;Gralinski, Lisa E.;Burton, Dennis R.;Andrabi, Raiees
通讯作者：
Andrabi, Raiees
DOI：
10.1056/nejmoa2107659
发表时间：
2021-09-23
期刊：
The New England journal of medicine
影响因子：
--
作者：
Heath PT;Galiza EP;Baxter DN;Boffito M;Browne D;Burns F;Chadwick DR;Clark R;Cosgrove C;Galloway J;Goodman AL;Heer A;Higham A;Iyengar S;Jamal A;Jeanes C;Kalra PA;Kyriakidou C;McAuley DF;Meyrick A;Minassian AM;Minton J;Moore P;Munsoor I;Nicholls H;Osanlou O;Packham J;Pretswell CH;San Francisco Ramos A;Saralaya D;Sheridan RP;Smith R;Soiza RL;Swift PA;Thomson EC;Turner J;Viljoen ME;Albert G;Cho I;Dubovsky F;Glenn G;Rivers J;Robertson A;Smith K;Toback S;2019nCoV-302 Study Group
通讯作者：
2019nCoV-302 Study Group
两种抗体鸡尾酒中和中和的遗传和结构基础。
影响因子：
28.3
作者：
Dong J;Zost SJ;Greaney AJ;Starr TN;Dingens AS;Chen EC;Chen RE;Case JB;Sutton RE;Gilchuk P;Rodriguez J;Armstrong E;Gainza C;Nargi RS;Binshtein E;Xie X;Zhang X;Shi PY;Logue J;Weston S;McGrath ME;Frieman MB;Brady T;Tuffy KM;Bright H;Loo YM;McTamney PM;Esser MT;Carnahan RH;Diamond MS;Bloom JD;Crowe JE Jr
通讯作者：
Crowe JE Jr