Folic acid supplementation use and the MTHFR C677T polymorphism in orofacial clefts etiology: An individual participant data pooled-analysis.
Folic acid supplementation use and the MTHFR C677T polymorphism in orofacial clefts etiology: An individual participant data pooled-analysis.
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DOI：
10.1002/bdra.23133
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发表时间：
2013-08
影响因子：
--
通讯作者：
Mossey, Peter A.
中科院分区：
文献类型：
--
作者：
Butali, Azeez;Little, Julian;Chevrier, Cecile;Cordier, Sylvian;Steegers-Theunissen, Regine;Jugessur, Astanand;Oladugba, Bola;Mossey, Peter A.
本研究旨在探讨MTHFR C667 T多态性和叶酸在口面裂（OFC）病因学中的基因-环境相互作用（GEI）。我们在四项使用类似方法的研究中使用了汇总分析方法。我们使用逻辑回归分析1149例孤立病例和1161例对照的合并样本。比较两组胎儿和母亲MTHFR C677 T基因型，母亲孕期暴露于吸烟、饮酒、含叶酸维生素和叶酸补充剂的情况。母体使用叶酸（p=0.008; OR=0.70，95% CI：0.65-0.94）和补充叶酸（p=0.028，OR=0.80，95% CI：0.65-0.94）可降低CL（P）风险。母亲吸烟增加了CL（P）（p<10 e −3; OR=1.62，95%CI：1.35-1.95）和CP（p=0.028; OR=1.38，95%CI：1.04-1.83）的风险。母亲或胎儿MTHFR C677 T基因型均未观察到显著风险。这种个体参与者数据（IPD）荟萃分析提供了更大的统计能力，可以帮助缓解与聚合级数据共享相关的问题。该IPD荟萃分析的结果与先前的报告一致，表明叶酸和吸烟影响OFC结局。
This study examines gene-environment interaction (GEI) between the MTHFR C667T polymorphism and folic acid in the etiology of orofacial clefts (OFC). We used a pooled-analyticapproach on four studies that used similar methods. We used logistic regression to analyse the pooled sample of 1149 isolated cases and 1161 controls. Fetal and maternal MTHFR C677T genotypes, and maternal periconceptional exposure to smoking, alcohol, vitamin containing folic acid and folic acid supplements were contrasted between the cleft types [non-syndromic clefts lip or without cleft palate (CL(P)) and non syndromic cleft palate (CP)] and control groups. There was a reduced risk of CL(P) with maternal folic acid use (p=0.008; OR=0.70, 95% CI: 0.65–0.94) and with supplements containing folic acid (p=0.028, OR=0.80, 95% CI: 0.65–0.94). Maternal smoking increased the risk of both CL(P) (p<10e−3; OR=1.62, 95% CI: 1.35–1.95) and CP (p=0.028; OR=1.38, 95% CI: 1.04–1.83). No significant risk was observed with either maternal or fetal MTHFR C677T genotypes. This individual paticipant data (IPD) meta-analysis affords greater statistical power and can help alleviate the problems associated with aggregate-level data-sharing. The result of this IPD meta-analysis is consistent with previous reports suggesting that folic acid and smoking influence OFC outcomes.
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影响因子：
1.1
作者：
Little, J.;Gilmour, M.;Fryer, A. E.
通讯作者：
Fryer, A. E.
影响因子：
2
作者：
Verldeij-Hagoort, Anna;Bliek, Johannes;Steegers-Theunissen, Regine
通讯作者：
Steegers-Theunissen, Regine
影响因子：
2
作者：
Zhu, JH;Ren, AG;Li, Z
通讯作者：
Li, Z
影响因子：
2
作者：
Chevrier, Cecile;Perret, Claire;Cordier, Sylvaine
通讯作者：
Cordier, Sylvaine
影响因子：
3.8
作者：
Jia, Z-L;Shi, B.;Xu, X.
通讯作者：
Xu, X.